Supplement
Sulbutiamine is a lab-made compound built from two thiamine (vitamin B1) molecules, a form that dissolves in fat and reaches the brain more easily than plain thiamine. The little research so far looked at people with type 2 diabetes, and the evidence is very limited: blood glucose and nerve-related symptoms showed no clear difference. That comes from one small open trial of 30 people, so it says little beyond that group.
Sources: PMID 22969314
- Updated
- How we grade
- 1 study cited
- Best evidence
- Grade D
- Conditions studied
- 2
- Outcomes
- 6
- Graded outcomes
- 0003
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Diabetic Neuropathy Symptoms No effect | NoneNo effect | 1 study | 30 people | |||
Studies that measured diabetic neuropathy symptoms | ||||||
| Blood glucose No effect | NoneNo effect | 30 people | ||||
| HbA1c | Improves (the measure goes down) | 30 people | ||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood glucose No effect | NoneNo effect | 30 people | ||||
| Diabetic Neuropathy Symptoms | Improves (the measure goes down) | 1 study | 30 people | |||
Studies that measured diabetic neuropathy symptoms | ||||||
| HbA1c | Improves (the measure goes down) | 30 people | ||||
Key findings
- Diabetic Neuropathy Symptoms
- Blood glucose
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- Grade D
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Studies cited
1 study from PubMed