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Guduchi

Guduchi is a climbing vine used in Ayurvedic medicine, and its plant compounds appear to influence how immune cells behave. People often look at it for seasonal allergies, and among 75 people with hay fever, symptoms eased and eosinophils, a white blood cell involved in allergic reactions, went down. The evidence is limited, though, and a small trial in diabetic foot ulcers found no clear difference.

Sources: PMID 17558098

Updated 30 September 2026
How we grade

Best evidence: Grade C
Conditions studied: 6
Outcomes: 20
Graded outcomes: 0033

Evidence by condition

Strong
Moderate
Limited
Very limited

6 conditions

Allergic Rhinitis (Seasonal Allergies / Hay Fever)

Allergic Rhinitis (Seasonal Allergies / Hay Fever): outcomes studied for Guduchi
Grade	Outcome	Effect	Size	Studies	People
	Allergy Symptoms Large Improvement	Improves (the measure goes down)	Large effect		75 people
	Eosinophil count Moderate Decrease	Improves (the measure goes down)	Moderate effect		75 people
	Lymphocyte Count	Improves (the measure goes up)		1 study	150 people
Studies that measured lymphocyte count Efficacy of Tinospora cordifolia in allergic rhinitisJ Ethnopharmacol · PMID 15619563
	Nasal Congestion	Improves (the measure goes up)			75 people
	Neutrophil Count	Improves (the measure goes up)			75 people

Immune Health

Immune Health: outcomes studied for Guduchi
Grade	Outcome	Effect	Size	Studies	People
	Allergy Symptoms Large Improvement	Improves (the measure goes down)	Large effect		75 people
	Lymphocyte Count	Improves (the measure goes up)		1 study	150 people
Studies that measured lymphocyte count Efficacy of Tinospora cordifolia in allergic rhinitisJ Ethnopharmacol · PMID 15619563
	Eosinophil count	Changes; see studies			75 people
	Nasal Congestion	Improves (the measure goes up)			75 people
	Neutrophil Count	Improves (the measure goes up)			75 people

Diabetic Foot Ulcers

Diabetic Foot Ulcers Symptoms
Neutrophil Count: improves

Diabetic Foot Ulcers: outcomes studied for Guduchi
Grade	Outcome	Effect	Size	Studies	People
	Diabetic Foot Ulcers Symptoms No effect		NoneNo effect	1 study	45 people
Studies that measured diabetic foot ulcers symptoms Immunomodulatory role of Tinospora cordifolia as an adjuvant in surgical treatment of diabetic foot ulcers: a prospective randomized controlled studyIndian J Med Sci · PMID 17558098
	Neutrophil Count	Improves (the measure goes up)			45 people

Human Immunodeficiency Virus (HIV)

CD4 Lymphocytes
HIV Symptoms: improves
Eosinophil count: changes; see studies

Human Immunodeficiency Virus (HIV): outcomes studied for Guduchi
Grade	Outcome	Effect	Size	Studies	People
	CD4 Lymphocytes No effect		NoneNo effect		68 people
	HIV Symptoms	Improves (the measure goes down)		1 study	68 people
Studies that measured hiv symptoms Immunomodulatory effect of Tinospora cordifolia extract in human immuno-deficiency virus positive patientsIndian J Pharmacol · PMID 20040936
	Eosinophil count	Changes; see studies			68 people
	Neutrophil Count	Improves (the measure goes up)			68 people
	T Cell Count	Improves (the measure goes up)			68 people

Sepsis

Bilirubin
Macrophage Activity: improves

Sepsis: outcomes studied for Guduchi
Grade	Outcome	Effect	Size	Studies	People
	Bilirubin No effect		NoneNo effect		57 people
	Macrophage Activity	Improves (the measure goes up)		1 study	57 people
Studies that measured macrophage activity Can we do away with PTBDHPB Surg · PMID 8857447

Scabies

Scabies Symptoms: improves

Scabies: outcomes studied for Guduchi
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Scabies Symptoms	Improves (the measure goes down)		1 study	66 people
Studies that measured scabies symptoms Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trialJ Pharmacol Pharmacother · PMID 23662023

Key findings

Allergy SymptomsAllergic Rhinitis (Seasonal Allergies / Hay Fever)Improves (the measure goes down)
Eosinophil countAllergic Rhinitis (Seasonal Allergies / Hay Fever)Improves (the measure goes down)
Diabetic Foot Ulcers SymptomsDiabetic Foot Ulcers

Shop Guduchi

Third-party tested Guduchi products. The evidence above is limited, so read it before you buy.

Grade C

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