King of Bitters

Andrographis paniculata is an herb frequently used in traditional medicines to treat the common cold.

Quick Answer

What it is

Andrographis paniculata is an herb frequently used in traditional medicines to treat the common cold.

Key findings

Grade B: Upper Respiratory Tract Infection Symptoms (Common Cold)
Grade C: Sore Throat Symptoms (Common Cold)
Grade D: CD4 Lymphocytes (Human Immunodeficiency Virus (HIV))

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: King of Bitters

Quick Facts: King of Bitters

Best Evidence:Grade B
Conditions Studied:6
Research Outcomes:12
Grade B Findings:1
Key Effect:Common Cold

Outcomes by grade:

A0

B1

C2

D2

6 conditions · 12 outcomes

Detailed Outcomes

Grade:

Effect:

Size:

Sort:

|

B

Upper Respiratory Tract Infection Symptoms

Moderate Improvement

316 participants

moderate↓Improves

C

Sore Throat Symptoms

Moderate Improvement

152 participants

moderate↓Improves

C

Sore Throat Symptoms

Moderate Improvement

152 participants

moderate↓Improves

?

Upper Respiratory Tract Infection Risk

223 participants

↑Worsens

D

CD4 Lymphocytes

No effect

34 participants

none

?

Early Virologic Response

1 study17 participants

↑Improves

?

Liver Enzymes

1 study17 participants

↑Worsens

D

CD4 Lymphocytes

No effect

34 participants

none

?

Early Virologic Response

1 study17 participants

↑Improves

?

Liver Enzymes

1 study17 participants

↑Worsens

?

Ulcerative Colitis Symptoms

344 participants

↓Improves

?

Rheumatoid Arthritis Symptoms

58 participants

↓Improves

Evidence by Condition

Best grade per condition (each condition may have multiple outcomes)

2 outcomes · 3 studies

↓Upper Respiratory Tract Infection SymptomsImproves↓Sore Throat SymptomsImproves

BUlcerative Colitis

1 outcome · 2 studies

↓Ulcerative Colitis SymptomsImproves

CUpper Respiratory Tract Infection

1 outcome · 2 studies

↓Sore Throat SymptomsImproves↑Upper Respiratory Tract Infection RiskWorsens

DHuman Immunodeficiency Virus (HIV)

1 outcome · 4 studies

CD4 Lymphocytes↑Early Virologic ResponseImproves↑Liver EnzymesWorsens

1 outcome · 4 studies

CD4 Lymphocytes↑Early Virologic ResponseImproves↑Liver EnzymesWorsens

Research Citations (7)

A phase I trial of andrographolide in HIV positive patients and normal volunteers

A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection

Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults

J Med Assoc Thai

Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study

Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial

Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine

Aliment Pharmacol Ther

Andrographis paniculata Extract (HMPL-004) for Active Ulcerative Colitis

Am J Gastroenterol

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