Supplement
Akkermansia muciniphila is a bacterium that lives in the gut's mucus lining, where it helps support the gut barrier and metabolism. In a trial of 90 people, a pasteurized form improved insulin sensitivity by about 29% over placebo, and a smaller study found lower insulin levels in metabolic syndrome. The evidence is limited, though: studies were small, and blood sugar and weight benefits appeared only in some people.
- Updated
- How we grade
- 3 studies cited
- Best evidence
- Grade C
- Conditions studied
- 6
- Outcomes
- 6
- Graded outcomes
- 0060
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
Insulin Resistance
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Insulin Sensitivity +28.6% improvement in insulin sensitivity vs placebo (pasteurized form) | Improves (the measure goes up) | Moderate effect | 90 people |
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Insulinemia -34% reduction in plasma insulin levels | Improves (the measure goes down) | Moderate effect | 32 people |
Cholesterol
- Total Cholesterol: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Total Cholesterol -8.7% reduction in total cholesterol | Improves (the measure goes down) | Small effect | 32 people |
Type 2 Diabetes
- HbA1c: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| HbA1c Significant reduction in HbA1c (only in those with low baseline A. muciniphila) | Improves (the measure goes down) | Moderate effect | 58 people |
Obesity
- Body Weight: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Body Weight Significant reduction in body weight and fat mass (responders only) | Improves (the measure goes down) | Small effect | 58 people |
Liver Health
- Liver Function Markers: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Liver Function Markers Reduced markers of liver dysfunction and inflammation | Improves (the measure goes down) | Small effect | 32 people |
Key findings
- Insulin SensitivityImproves (the measure goes up)
- InsulinemiaImproves (the measure goes down)
- Total CholesterolImproves (the measure goes down)
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Third-party tested Akkermansia muciniphila products. The evidence above is limited, so read it before you buy.
- Grade C
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Studies cited
3 studies from PubMed
- Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut
- A comprehensive systematic review of the effectiveness of Akkermansia muciniphila for the management of obesity and associated metabolic disorders
- Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study