Supplement
7-Keto DHEA is a compound the body makes as a byproduct of the hormone DHEA, though unlike DHEA it does not convert into sex hormones. People mostly look at it for weight management in obesity, and the evidence is very limited: small studies hinted at a slight rise in resting metabolic rate and some fat loss. Both findings came from manufacturer-funded or conflict-of-interest research in a few dozen people, and blood sugar and blood pressure showed no clear difference.
Sources: PMID 17418559
- Updated
- How we grade
- 1 study cited
- Best evidence
- Grade D
- Conditions studied
- 2
- Outcomes
- 22
- Graded outcomes
- 0008
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Metabolic Rate Possible increase in resting metabolic rate - manufacturer funded | Improves (the measure goes up) | Small effect | 1 study | 40 people | ||
| Body Fat Possible fat loss but study has conflict of interest | Improves (the measure goes down) | Small effect | 23 people | |||
| Blood Glucose No effect on blood glucose | NoneNo effect | 23 people | ||||
| Blood Pressure No effect on blood pressure | NoneNo effect | 23 people | ||||
| Testosterone No effect on testosterone levels (expected - non-hormonal) | NoneNo effect | 23 people | ||||
| Estrogen No effect on estrogen levels (expected - non-hormonal) | NoneNo effect | 23 people | ||||
| Blood glucose No effect | NoneNo effect | 23 people | ||||
| Fatigue Symptoms | Changes; see studies | 23 people | ||||
| Parathyroid Hormone | Improves (the measure goes up) | 23 people | ||||
| Serum T3 | Improves (the measure goes up) | 23 people | ||||
| Serum T4 | Improves (the measure goes up) | 23 people | ||||
| Weight | Changes; see studies | 23 people | ||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood glucose No effect | NoneNo effect | 23 people | ||||
| Blood Pressure | Changes; see studies | 23 people | ||||
| Body Fat | Changes; see studies | 23 people | ||||
| Estrogen | Changes; see studies | 23 people | ||||
| Fatigue Symptoms | Changes; see studies | 23 people | ||||
| Parathyroid Hormone | Improves (the measure goes up) | 23 people | ||||
| Serum T3 | Improves (the measure goes up) | 23 people | ||||
| Serum T4 | Improves (the measure goes up) | 23 people | ||||
| Testosterone | Improves (the measure goes up) | 23 people | ||||
| Weight | Changes; see studies | 23 people |
Key findings
- Metabolic RateImproves (the measure goes up)
- Body FatImproves (the measure goes down)
- Blood Glucose
Shop 7-Keto DHEA
Third-party tested 7-Keto DHEA products. The evidence above is limited, so read it before you buy.
- Grade D
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Studies cited
1 study from PubMed