Condition
Orthostatic Hypotension
Orthostatic hypotension is a sharp blood pressure drop on standing that brings lightheadedness, blurred vision and sometimes fainting, often from dehydration, medications or autonomic nerve problems. The evidence is strongest for sodium, which expands blood volume, and in one small trial of 31 people with autonomic failure, yohimbine eased symptoms. That yohimbine evidence is limited, and it mostly applies to people whose condition has a nerve-related cause.
Sources: PMID 20837887
- Supplements studied
- 1
- Graded outcomes
- 1
- Trials
- 1
- People studied
- 31
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Orthostatic Hypotension Symptoms Small Improvement | Improves (the measure goes down) | Small effect | 1 study | 31 people | ||
Studies that measured orthostatic hypotension symptoms | ||||||
Key findings
- Orthostatic Hypotension SymptomsImproves (the measure goes down)
The Orthostatic Hypotension (Low Blood Pressure on Standing) Supportive Care protocol
2 primary supplements · 6 supporting supplements
- Electrolytes (Sodium)2–4 g extra sodium daily (salt tablets or high-sodium foods) with 2–3 L fluids
- Vitamin B121,000–2,500 mcg daily if deficient or borderline
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Orthostatic Hypotension. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
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Studies cited
11 studies from PubMed
- Melatonin responses to clonidine and yohimbine challenges
- Psychological and neuroendocrine responses to social stress and to the administration of the alpha-2-receptor antagonist, yohimbine, in highly trained endurance athletes in comparison to untrained healthy controls
- Effects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humans
- Yohimbine treatment of organic erectile dysfunction in a dose-escalation trial
- Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials
- Yohimbine: the effects on body composition and exercise performance in soccer players
- Facilitation of fear extinction in phobic participants with a novel cognitive enhancer: a randomized placebo controlled trial of yohimbine augmentation
- Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate
- Effect of anti-obesity drugs promoting energy expenditure, yohimbine and ephedrine, on gastric emptying in obese patients
- Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure
- Does yohimbine hydrochloride facilitate fear extinction in virtual reality treatment of fear of flying? A randomized placebo-controlled trial