C
Body Fat
Moderate decrease in body fat during caloric restriction
20 participants
moderate↓Improves
?
Muscle Mass
1 study20 participants
↑Improves
?
Power Output
1 study20 participants
↑Improves
Yohimbine
Yohimbine is an alpha-2 adrenergic receptor antagonist from the Pausinystalia yohimbe tree bark. C-grade evidence for fat loss and erectile dysfunction. SIGNIFICANT SAFETY CONCERNS: Causes anxiety, elevated heart rate, and blood pressure increases - contraindicated in cardiovascular conditions, anxiety disorders, and panic disorder. Supplement quality is notoriously poor - actual yohimbine content varies widely from label claims. Effective for fat loss during fasted cardio but side effects limit use.
Quick Answer
What it is
Yohimbine is an alpha-2 adrenergic receptor antagonist from the Pausinystalia yohimbe tree bark. C-grade evidence for fat loss and erectile dysfunction.
Key findings
- Grade C: Body Fat (Body Composition)
- Grade C: Erections (Male Sexual Dysfunction)
- Grade C: Penile Girth (Male Sexual Dysfunction)
Safety
- ADVERSE: Significant increase in anxiety
- ADVERSE: Small worsening of symptoms
ℹ️ Quick Facts: Yohimbine
Quick Facts: Yohimbine
- Best Evidence:Grade C
- Conditions Studied:13
- Research Outcomes:25
- Key Effect:Body Composition
Outcomes by grade:
A0
B0
C10
D0
13 conditions · 25 outcomes
Detailed Outcomes
Grade:
Effect:
Size:
Sort:
|
C
Erections
Small improvement in erectile function
419 participants
small↑Improves
C
Penile Girth
Small improvement during erection
1 study18 participants
small↑Improves
?
Testosterone
18 participants
↑Improves
C
Diuresis
Mild diuretic effect
10 participants
small↑Improves
?
Plasma Melatonin
1 study10 participants
↑Improves
C
Anxiety Symptoms
ADVERSE: Significant increase in anxiety
1 study24 participants
moderate↑Worsens
?
Cortisol
24 participants
↑Worsens
?
Heart Rate
24 participants
↑Worsens
C
Alcohol Dependence Symptoms
ADVERSE: Small worsening of symptoms
1 study35 participants
small↑Worsens
?
Anxiety Symptoms
1 study35 participants
↑Worsens
?
Cortisol
35 participants
↑Worsens
C
Phobia Symptoms
Small Improvement
24 participants
small↓Improves
C
Orthostatic Hypotension Symptoms
Small Improvement
31 participants
small↓Improves
C
Phobia Symptoms
Small Improvement
48 participants
small↓Improves
C
Body Fat
Moderate Decrease
20 participants
moderate↓Improves
?
Muscle Mass
1 study20 participants
↑Improves
?
Power Output
1 study20 participants
↑Improves
?
Orthostatic Hypotension Symptoms
31 participants
↑Worsens
?
Gastric Emptying Rate
23 participants
↑Improves
?
Blood Pressure
Small Detriment
9 participants
small
?
Cerebral Blood Flow
1 study9 participants
↑Improves
?
Orthostatic Hypotension Symptoms
31 participants
↑Worsens
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (11)
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