Longer Lifespan
Lifespan refers to the length of time that a person lives and is sometimes referred to as longevity.
Quick Answer
What it is
Lifespan refers to the length of time that a person lives and is sometimes referred to as longevity.
Key findings
- Grade D: Telomere Length (Astragalus)
- Grade N/A: All-Cause Mortality (Vitamin D)
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
ℹ️ Quick Facts
Quick Facts: Longer Lifespan
- Supplements Studied:2
- Research Trials:2
- Total Participants:108,682
- Top Supplement:Astragalus (D)
Evidence-Based Protocol
Supplement stack ranked by research quality
Primary Stack (Tier 1)
Reduces inflammation; supports cardiovascular health; associated with longer telomeres in some studies
Deficiency associated with increased mortality; supports bone, immune, and cardiovascular health
Supporting Stack (Tier 2)
Essential for hundreds of enzymes; deficiency common with aging; supports cardiovascular and metabolic health
Mitochondrial energy production; antioxidant; levels decline with age; supports heart function
NAD+ precursors; NAD+ declines with age; supports mitochondrial function and sirtuins
Sirtuin activator; mimics caloric restriction effects; antioxidant and anti-inflammatory
Potent anti-inflammatory; neuroprotective; supports cardiovascular and joint health
Directs calcium to bones, away from arteries; may reduce vascular calcification and fracture risk
Amino acid that supports collagen synthesis, sleep quality, and may have anti-aging effects on cells
Antioxidant; regenerates other antioxidants; supports mitochondrial function and glucose metabolism
How It Works
Longevity research has identified several hallmarks of aging: genomic instability, telomere shortening, epigenetic changes, loss of proteostasis, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, inflammation, and nutrient sensing dysregulation. While no supplement has been proven to extend human lifespan, some may support healthy aging processes.
THE FOUNDATIONS OF LONGEVITY:
1. Diet: Mediterranean diet, intermittent fasting, caloric moderation
2. Exercise: Regular aerobic and resistance training
3. Sleep: 7-9 hours quality sleep
4. Social connection: Strong relationships extend life
5. Purpose: Having meaning and engagement
6. Not smoking: Single biggest modifiable risk factor
7. Moderate alcohol: Or none
8. Stress management: Chronic stress accelerates aging
SUPPLEMENTS TARGET:
* Omega-3 Fatty Acids reduce inflammation and support cardiovascular health.
* Vitamin D deficiency is associated with increased all-cause mortality.
* NAD+ precursors (NR, NMN) are promising but long-term human data limited.
* Resveratrol activates sirtuins similar to caloric restriction.
Expected timeline: Longevity effects take years to decades. Supplements support daily health and may compound over time. Focus on lifestyle foundations first.
Supplements for Longer Lifespan
Sorted by strength of evidence
Detailed Outcomes
Research Citations (100)
Related Conditions
Immune Health
2 shared supplements · 409 outcomes
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Weight Loss & Maintenance
1 shared supplement · 433 outcomes
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Vitamin D Deficiency
1 shared supplement · 2 outcomes
Vitamin D deficiency occurs when a person isn't getting enough vitamin D to stay healthy. This deficiency can result in a loss of bone density, leading to osteoporosis and fractures. Severe vitamin D deficiency can cause other diseases such as rickets and osteomalacia.
Uremic Pruritus
1 shared supplement · 3 outcomes
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Upper Respiratory Tract Infection
1 shared supplement · 49 outcomes
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Type 2 Diabetes
1 shared supplement · 868 outcomes
Type 2 diabetes (T2D) is a disease in which blood glucose levels are too high. It is characterized by insulin resistance in muscle, fat, and pancreas cells and an inability of the pancreas to manufacture enough insulin to control blood glucose levels. T2D is strongly associated with excess body fat, and weight loss induced by lifestyle changes is extremely effective for treating T2D.
Type 1 Diabetes
1 shared supplement · 76 outcomes
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Tuberculosis (TB)
1 shared supplement · 3 outcomes
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