Nicotinamide Riboside

Nicotinamide riboside (NR) is a vitamin B3 form and NAD+ precursor that reliably increases blood NAD+ levels by 40-90% at typical doses. GRAS status and well-tolerated up to 3000mg/day. Despite strong preclinical data (longevity, mitochondrial function, neurodegeneration models), human trials show DISAPPOINTING clinical efficacy - NAD+ elevation doesn't consistently translate to functional benefits in healthy adults. C-grade evidence only for IL-8 reduction in COPD. More promising in conditions with NAD+ depletion (aging, metabolic disease). Compare to NMN which has similar mechanism but less human data.

Quick Answer

What it is

Nicotinamide riboside (NR) is a vitamin B3 form and NAD+ precursor that reliably increases blood NAD+ levels by 40-90% at typical doses. GRAS status and well-tolerated up to 3000mg/day.

Key findings

Grade C: Interleukin 8 (Chronic Obstructive Pulmonary Disease (COPD))

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Nicotinamide Riboside

Quick Facts: Nicotinamide Riboside

Best Evidence:Grade C
Conditions Studied:1
Research Outcomes:1
Key Effect:Chronic Obstructive Pulmonary Disease (COPD)

Outcomes by grade:

1 conditions · 1 outcomes

Detailed Outcomes

Interleukin 8

Small Decrease

58 participants

small↓Improves

Evidence by Condition

Best grade per condition (each condition may have multiple outcomes)

CChronic Obstructive Pulmonary Disease (COPD)

1 outcome · 1 study

↓Interleukin 8Improves

Research Citations (1)

Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial.

Nat Aging

PMID: 39548320

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