Supplement
Nicotinamide riboside is a form of vitamin B3 that cells convert into NAD+, a molecule central to energy production and to sirtuin proteins. People mostly look at it for healthy aging, since NAD+ levels decline over the years, but the evidence for that use is limited. One small trial in 58 people with COPD found that interleukin 8, an inflammation marker, went down, though that is a single study.
Sources: PMID 39548320
- Updated
- How we grade
- 1 study cited
- Best evidence
- Grade C
- Conditions studied
- 1
- Outcomes
- 1
- Graded outcomes
- 0010
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Interleukin 8 Small Decrease | Improves (the measure goes down) | Small effect | 1 study | 58 people | ||
Studies that measured interleukin 8 | ||||||
What the published studies found
1 automated reading
All-cause mortality
The studies read are too weak to tell whether Nicotinamide Riboside changes all-cause mortality. They lean toward an improvement, which is not enough to claim one. The evidence is very weak.
1 study counted of 8 read.
- Study, 2024; mice with systemic frataxin knockdown: improves.
riboside to shFxn mice increases survival
NAD+ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich's Ataxia
- Study, 2024; mice with systemic frataxin knockdown: improves.
Key findings
- Interleukin 8Improves (the measure goes down)
Shop Nicotinamide Riboside
Third-party tested Nicotinamide Riboside products. The evidence above is limited, so read it before you buy.
- Grade C
Links to Fullscript, iHerb or Thorne carry our referral, so we may earn a commission at no extra cost to you. Grades come from the research and never change based on what we earn. Fullscript asks for a free account before it shows its catalog and prices. Full disclosure
Studies cited
1 study from PubMed