Condition
Liver Fibrosis
Liver fibrosis is a buildup of scar tissue in the liver, which happens when long-term injury or inflammation switches on stellate cells that lay down too much of the fibrous material between liver cells. Among supplements, TB-500, a synthetic version of a thymosin beta 4 fragment, has the most to show so far, and lab models found it calmed those stellate cells and reduced scar-tissue buildup. The evidence is limited, though, because the work was mostly in animals or cell studies, so it says little yet about what happens in people.
Sources: PMID 26006229; PMID 34280397
- Updated
- How we grade
- 84 studies cited
- Supplements studied
- 0
- Medicines and peptides
- 1
- Graded outcomes
- 1
No supplement studies yetWe haven’t found supplement studies for Liver Fibrosis. The medicines and peptides studied for it are listed below.
Prescription medicines and peptides studied, for context
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Liver Fibrosis Protection Regulates hepatic stellate cell activation. Reduces extracellular matrix deposition. Anti-fibrotic effects demonstrated in preclinical liver injury models. | Improves (the measure goes down) | Moderate effect | 5 studies | 60 people | ||
Studies that measured liver fibrosis protection
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Key findings
- Liver Fibrosis ProtectionImproves (the measure goes down)
Studies cited
84 studies from PubMed
- Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids
- Thymosin Beta-4 Modulates Cardiac Remodeling by Regulating ROCK1 Expression in Adult Mammals
- CCN5 suppresses injury-induced vascular restenosis by inhibiting smooth muscle cell proliferation and facilitating endothelial repair via thymosin β4 and Cd9 pathway.
- Tβ4-exosome-loaded hemostatic and antibacterial hydrogel to improve vascular regeneration and modulate macrophage polarization for diabetic wound treatment.
- Corrigendum to 'Tβ4-exosome-loaded hemostatic and antibacterial hydrogel to improve vascular regeneration and modulate macrophage polarization for diabetic wound treatment' [Mater. Today Bio,Volume 31, 2025, 101585].
- Mechanistic study of the Tβ4/SLC7A11 signaling pathway regulating breast cancer evolution.
- Identification of glutamine as a potential therapeutic target in dry eye disease.
- Epimedin C promotes mitochondrial transfer and delays thymus atrophy in 4-VCD induced mimetic-menopausal mice.
- Thymosin β4 Regulates Tissue Inflammatory Response in Mouse Nonalcoholic Fatty Liver Disease by Promoting Macrophage M2-Type Polarization.
- Tβ4-Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing.
- Enhancing fat graft survival: thymosin beta-4 facilitates mitochondrial transfer from ADSCs via tunneling nanotubes by upregulating the Rac/F-actin pathway.
- Comparative effects of dietary sodium butyrate and tributyrin on broiler chickens' performance, gene expression, intestinal histomorphometry, blood indices, and litter.
- Recombinant human thymosin beta 4 improves ischemic cardiac dysfunction in mice and patients with acute ST-segment elevation myocardial infarction after reperfusion.
- In Vitro Study of Thymosin Beta 4 Promoting Transplanted Fat Survival by Regulating Adipose-Derived Stem Cells.
- Thymosin β(4) and β(10) Expression in Human Organs during Development: A Review.
- Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies
- Thymosin beta-4 - A potential tool in healing middle ear lesions in adult mammals
- Targeted Deletion of Thymosin Beta 4 in Hepatic Stellate Cells Ameliorates Liver Fibrosis in a Transgenic Mouse Model
- Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome.
- Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of low density lipoprotein related protein 1 (LRP1).
- Thymosin beta-4 participate in antibacterial immunity and wound healing in black tiger shrimp, Penaeus monodon.
- Thymosin Beta 4 Inhibits LPS and ATP-Induced Hepatic Stellate Cells via the Regulation of Multiple Signaling Pathways.
- The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus.
- The preliminary study of exosomes derived from thymosin beta 4-treated adipose-derived stem cells in fat grafting.
- Thymosin beta-4 improves endothelial function and reparative potency of diabetic endothelial cells differentiated from patient induced pluripotent stem cells.
- Aberrant Expression of Thymosin Beta-4 Correlates With Advanced Disease and BRAF V600E Mutation in Thyroid Cancer.
- The Role of Tβ4-POP-Ac-SDKP Axis in Organ Fibrosis.
- Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4
- Thymosin beta-4 prenatal administration improves fetal development and halts side effects due to preterm delivery
- Association between Thymosin beta-4, acute kidney injury, and mortality in patients with sepsis: An observational cohort study
- Adjunctive Thymosin Beta-4 Treatment Influences PMN Effector Cell Function during Pseudomonas aeruginosa-Induced Corneal Infection.
- Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State-New Directions in Anti-Aging Regenerative Therapies.
- Thymosin-β4 induces angiogenesis in critical limb ischemia mice via regulating Notch/NF-κB pathway
- Thymosin beta 4 attenuates PrP(106-126)-induced human brain endothelial cells dysfunction.
- Antimicrobial Effects of Thymosin Beta-4 and Ciprofloxacin Adjunctive Therapy in Pseudomonas aeruginosa Induced Keratitis.
- Thymosin β4: A Multi-Faceted Tissue Repair Stimulating Protein in Heart Injury
- miR-200a mediates protection of thymosin β-4 in cardiac microvascular endothelial cells as a novel mechanism under hypoxia-reoxygenation injury.
- Inhibition of microRNA-34a mediates protection of thymosin beta 4 in endothelial progenitor cells against advanced glycation endproducts by targeting B-cell lymphoma 2.
- Thymosin β-4 is a novel regulator for primary cilium formation by nephronophthisis 3 in HeLa human cervical cancer cells.
- Ethosomal Gel for Improving Transdermal Delivery of Thymosin β-4.
- Thymosin beta 4 regulation of actin in sepsis
- Thymosin beta 4 and the eye: the journey from bench to bedside
- Sources of variability in quantifying circulating thymosin beta-4: literature review and recommendations.
- Thymosin beta-4 overexpression correlates with high-risk groups in gastric gastrointestinal stromal tumors: A retrospective analysis by immunohistochemistry.
- Targeted delivery of thymosin beta 4 to the injured myocardium using CREKA-conjugated nanoparticles.
- Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling.
- Potential role of thymosin beta 4 in the treatment of nonalcoholic fatty liver disease.
- Recombinant adeno-associated virus carrying thymosin β(4) suppresses experimental colitis in mice.
- Adsorption effects of the doping relevant peptides Insulin Lispro, Synachten, TB-500 and GHRP 5.
- Cardioprotection by Thymosin Beta 4
- Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases
- Thymosin Beta 4 Is a Potential Regulator of Hepatic Stellate Cells
- Comparison of various in vitro model systems of the metabolism of synthetic doping peptides: Proteolytic enzymes, human blood serum, liver and kidney microsomes and liver S9 fraction.
- Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells.
- Thymosin β4: multiple functions in protection, repair and regeneration of the mammalian heart
- Thymosin Beta-4 Induces Mouse Hair Growth
- Potential role of thymosin Beta 4 in liver fibrosis
- MALDI-imaging reveals thymosin beta-4 as an independent prognostic marker for colorectal cancer.
- Primary Mechanisms of Thymosin β4 Repair Activity in Dry Eye Disorders and Other Tissue Injuries.
- Thymosin Beta-4 Recombinant Adeno-associated Virus Enhances Human Nucleus Pulposus Cell Proliferation and Reduces Cell Apoptosis and Senescence.
- N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP): Potential target molecule in research of heart, kidney and brain.
- Thymosin beta 4 and thymosin beta 10 expression in hepatocellular carcinoma.
- Thymosin β4 enhances the healing of medial collateral ligament injury in rat
- Roles and mechanisms of β-thymosins in cell migration and cancer metastasis: an update.
- Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications
- The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients
- Thymosin beta 4 ameliorates hyperglycemia and improves insulin resistance of KK Cg-Ay/J mouse
- Thymosin β4: a potential molecular target for tumor therapy.
- No muscle for a damaged heart: thymosin beta 4 treatment after myocardial infarction does not induce myocardial differentiation of epicardial cells.
- Thymosin β4 and cardiac protection: implication in inflammation and fibrosis.
- Thymosins and muscle regeneration.
- Thymosin beta4 and cardiac repair
- Thymosin beta4 enhances repair by organizing connective tissue and preventing the appearance of myofibroblasts
- Thymosin beta4 regulates migration of colon cancer cells by a pathway involving interaction with Ku80.
- Progression of ocular sulfur mustard injury: development of a model system.
- Thymosin beta4 and corneal wound healing: visions of the future.
- Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin beta4.
- Thymosin beta4 is cardioprotective after myocardial infarction
- Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent
- Adhesive and proteolytic phenotype of migrating endothelial cells induced by thymosin beta-4.
- Localization of thymosin beta-4 in tumors.
- Antimicrobial peptides from human platelets.
- Thymosin beta4 accelerates wound healing
- Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells.