Infantile Colic
“Infantile colic” is characterized by repeated episodes of intense/frequent crying or discontent with an unknown cause. Caregivers need to be reassured that they are often doing nothing wrong, and that colic usually resolves by itself within 3–4 months. However, supplementation with certain probiotics may help.
Quick Answer
What it is
“Infantile colic” is characterized by repeated episodes of intense/frequent crying or discontent with an unknown cause. Caregivers need to be reassured that they are often doing nothing wrong, and that colic usually resolves by itself within 3–4 months.
Key findings
- Grade B: Infant crying (Lactobacillus reuteri)
- Grade C: Constipation Signs and Symptoms (Lactobacillus reuteri)
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
ℹ️ Quick Facts
Quick Facts: Infantile Colic
- Supplements Studied:1
- Research Trials:6
- Total Participants:3,597
- Top Supplement:Lactobacillus reuteri (B)
Evidence-Based Protocol
Supplement stack ranked by research quality
Primary Stack (Tier 1)
Best-studied probiotic for infant colic; reduces crying time; supports gut microbiome development
Reduces gas bubbles in gut; commonly used though evidence mixed
Supporting Stack (Tier 2)
Traditional remedy; may reduce intestinal spasms; some evidence for reducing colic symptoms
Traditional calming herb; may reduce intestinal spasms; often combined with fennel
May help if lactose intolerance contributing; breaks down lactose in breast milk or formula
Some research suggests vitamin D may help with colic; maternal supplementation benefits breast milk
How It Works
Infant colic is defined as episodes of crying for more than 3 hours a day, more than 3 days a week, for more than 3 weeks in an otherwise healthy infant. It typically starts around 2-3 weeks of age and usually resolves by 3-4 months. Colic affects about 10-25% of infants.
IMPORTANT: Colic is NOT harmful to the baby long-term, but it is extremely stressful for parents.
WHEN TO SEE A DOCTOR:
POSSIBLE CONTRIBUTING FACTORS:
NON-SUPPLEMENT STRATEGIES:
* Lactobacillus reuteri DSM 17938 is the most studied probiotic for colic. Multiple RCTs show it reduces crying time, especially in breastfed infants.
* Fennel has traditional use for infant digestive discomfort and some clinical evidence.
* Simethicone is commonly used for gas but evidence is mixed.
Expected timeline: Probiotics may show benefit within 1-2 weeks. Colic typically resolves by 3-4 months regardless of treatment.
Supplements for Infantile Colic
Sorted by strength of evidence
Detailed Outcomes
Research Citations (30)
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