Condition

H. Pylori Infection

H. pylori is a spiral-shaped bacterium that lives in the stomach lining, where it survives acid and can cause inflammation, gastritis, and ulcers. Probiotics have the strongest evidence, and abdominal pain eased in trials, while Lactobacillus reuteri, with moderate evidence, improved signs of infection across three studies. Those benefits were small, and the L. reuteri studies were few and mostly tested it alongside standard antibiotic therapy.

Sources: PMID 38846173; PMID 18321302

Supplements studied: 5
Graded outcomes: 4
Trials: 6
People studied: 21,098

Evidence by supplement

Strong
Moderate
Limited
Very limited

5 supplements

Probiotics

Probiotics: outcomes studied for H. Pylori Infection
Grade	Outcome	Effect	Size	Studies	People
	Abdominal Pain Moderate Improvement	Improves (the measure goes down)	Moderate effect		5,036 people
	Diarrhea Symptoms	Changes; see studies		4 studies	5,036 people
Studies that measured diarrhea symptoms Oral probiotic supplementation to alleviate diarrhea induced by fluoropyrimidines or irinotecan-based chemotherapy: A systematic review and meta-analysis.Complement Ther Med · PMID 39993479 Evaluation of the efficacy of probiotics in the chemoradiotherapy of colorectal cancer: a meta-analysis of Randomized Controlled Trials.BMC Gastroenterol · PMID 40301781 Efficacy and safety of Saccharomyces boulardii CNCM I-745 for the treatment of pediatric acute diarrhea in China: a systematic review and meta-analysis.Front Cell Infect Microbiol · PMID 40535538 and 1 more on the Probiotics page
	Helicobacter Pylori Infection Signs	Improves (the measure goes up)		2 studies	3,707 people
Studies that measured helicobacter pylori infection signs Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis.Front Cell Infect Microbiol · PMID 40012609 Efficacy of probiotics regimens for Helicobacter pylori eradication: A systematic review, pairwise, and network meta-analysis of randomized controlled trials.Clin Nutr ESPEN · PMID 39642994
	Adverse Events	Changes; see studies			2,413 people
	Bloating	Changes; see studies			5,036 people
	Constipation Signs and Symptoms	Changes; see studies			5,036 people
	Nausea Symptoms	Changes; see studies			5,036 people
	Vomiting	Changes; see studies			5,036 people

Lactobacillus reuteri

Lactobacillus reuteri: outcomes studied for H. Pylori Infection
Grade	Outcome	Effect	Size	Studies	People
	Helicobacter Pylori Infection Signs Small Improvement	Improves (the measure goes up)	Small effect	3 studies	1,087 people
Studies that measured helicobacter pylori infection signs Lactobacillus reuteri compared with placebo as an adjuvant in Helicobacter pylori eradication therapy: a meta-analysis of randomized controlled trials.Therap Adv Gastroenterol · PMID 38846173 Inhibition of Helicobacter pylori infection in humans by Lactobacillus reuteri ATCC 55730 and effect on eradication therapy: a pilot studyHelicobacter · PMID 18321302 Non-viable Lactobacillus reuteri DSMZ 17648 (Pylopass™) as a new approach to Helicobacter pylori control in humansNutrients · PMID 23917169
	Gastrointestinal symptoms Small Improvement	Improves (the measure goes down)	Small effect		396 people

Melatonin

Gastrin: improves
Ghrelin: improves
Leptin: improves

Melatonin: outcomes studied for H. Pylori Infection
Grade	Outcome	Effect	Size	Studies	People
	Gastrin Moderate Increase	Improves (the measure goes up)	Moderate effect		21 people
	Ghrelin	Improves (the measure goes up)		1 study	21 people
Studies that measured ghrelin Plasma insulin, leptin, adiponectin, resistin, ghrelin, and melatonin in nonalcoholic steatohepatitis patients treated with melatoninJ Pineal Res · PMID 22804755
	Leptin	Improves (the measure goes up)		1 study	21 people
Studies that measured leptin Effects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humansJ Physiol Pharmacol · PMID 22204799
	Stomach Ulcers	Improves (the measure goes up)			21 people

Curcumin

Stomach Ulcers: improves

Curcumin: outcomes studied for H. Pylori Infection
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Stomach Ulcers	Improves (the measure goes up)		1 study	36 people
Studies that measured stomach ulcers Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patientsInt Immunopharmacol · PMID 20438867

N-Acetylcysteine

Helicobacter Pylori Infection Signs: improves

N-Acetylcysteine: outcomes studied for H. Pylori Infection
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Helicobacter Pylori Infection Signs	Improves (the measure goes up)		1 study	1,167 people
Studies that measured helicobacter pylori infection signs The efficacy of adjuvant N acetyl cysteine for the eradication of H pylori infections: A systematic review and meta-analysis of randomized clinical trials.Clin Res Hepatol Gastroenterol · PMID 34775122

Key findings

Abdominal PainProbioticsImproves (the measure goes down)
Helicobacter Pylori Infection SignsLactobacillus reuteriImproves (the measure goes up)
Gastrointestinal symptomsLactobacillus reuteriImproves (the measure goes down)

The H. Pylori Infection protocol

2 primary supplements · 3 supporting supplements

Saccharomyces boulardii500–1,000 mg daily
Lactobacillus reuteri200 million CFU daily (DSM 17,938 strain)

See the full protocol

Shop the evidence-backed picks

Support alongside medical care. These supplements are not a treatment for H. Pylori Infection. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.

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The supplements graded A or B for H. Pylori Infection. Each opens third-party tested products for that supplement.

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Studies cited

2 studies from PubMed

A pilot study to determine the effectiveness of garlic oil capsules in the treatment of dyspeptic patients with Helicobacter pyloriHelicobacter · PMID 11683929
Garlic or jalapeño peppers for treatment of Helicobacter pylori infectionAm J Gastroenterol · PMID 10235193