Condition
Chronic Bronchitis
Chronic bronchitis is a form of COPD in which inflamed bronchial tubes make extra mucus, causing a productive cough on most days, usually because of smoking. Little research on supplements for it has been reviewed here so far, though N-acetylcysteine and vitamin D carry the strongest evidence. Both are studied mainly for fewer flare-ups, and vitamin D may matter most for people who are low in it.
Sources: PMID 30675873
- Supplements studied
- 1
- Graded outcomes
- 0
- Trials
- 1
- People studied
- 29
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Mucus Production | Improves (the measure goes up) | 4 studies | 29 people | |||
Studies that measured mucus production
| ||||||
The Chronic Bronchitis Support protocol
2 primary supplements · 7 supporting supplements
- N-Acetyl Cysteine (NAC)600–1,200 mg daily
- Vitamin D2,000–4,000 IU daily (higher if deficient)
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Chronic Bronchitis. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
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Studies cited
11 studies from PubMed
- The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial
- A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model
- A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling
- [Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-- a prospective study]
- Comparison of the roles of serratiopeptidase and dexamethasone in the control of inflammation and trismus following impacted third molar surgery
- Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo
- [Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase]
- Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease
- A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome
- Effect of expectorants on relaxation behavior of sputum viscoelasticity in vivo
- The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus