Condition
Inflammatory Venous Disease
Inflammatory venous disease, including chronic venous insufficiency and varicose veins, happens when inflamed, weakened veins and damaged valves let blood pool in the legs, causing swelling, pain and skin changes. Horse chestnut seed extract and diosmin-hesperidin have the strongest evidence, and in one small trial of 40 people, serrapeptase improved pain. Still, the serrapeptase evidence is limited, and compression stockings and exercise remain the foundation.
Sources: PMID 2688125
- Supplements studied
- 1
- Graded outcomes
- 1
- Trials
- 1
- People studied
- 40
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Pain Small Improvement | Improves (the measure goes down) | Small effect | 1 study | 40 people | ||
| Superficial Thrombophlebitis Symptoms | Improves (the measure goes down) | 1 study | 40 people | |||
Studies that measured superficial thrombophlebitis symptoms | ||||||
Key findings
- PainImproves (the measure goes down)
The Inflammatory Venous Disease Support protocol
2 primary supplements · 6 supporting supplements
- Horse Chestnut Seed Extract (Aescin)300 mg standardized extract (50 mg aescin) twice daily
- Diosmin-Hesperidin (Micronized Purified Flavonoid Fraction)500 mg twice daily or 1,000 mg once daily
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Inflammatory Venous Disease. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
We earn from purchases made in our Fullscript store, and links to Fullscript, iHerb or Thorne carry our referral, so we may earn a commission at no extra cost to you. Grades come from the research and never change based on what we earn. Full disclosure
Studies cited
11 studies from PubMed
- The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial
- A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model
- A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling
- [Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-- a prospective study]
- Comparison of the roles of serratiopeptidase and dexamethasone in the control of inflammation and trismus following impacted third molar surgery
- Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo
- [Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase]
- Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease
- A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome
- Effect of expectorants on relaxation behavior of sputum viscoelasticity in vivo
- The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus