Condition
Trismus
Trismus, often called lockjaw, is a limit on how wide the mouth opens, usually because the jaw muscles tighten or swell after surgery, injury or radiation. Serratiopeptidase, an enzyme supplement, has the most direct trial data, and studies after wisdom tooth surgery found inflammation went down. Those studies were small, about 110 people in all, so the evidence is limited and mostly reflects dental surgery.
Sources: PMID 23649050; PMID 19168326
- Supplements studied
- 1
- Graded outcomes
- 1
- Trials
- 1
- People studied
- 110
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Inflammation Small Decrease | Improves (the measure goes down) | Small effect | 4 studies | 110 people | ||
Studies that measured inflammation
| ||||||
| Pain | Improves (the measure goes down) | 1 study | 110 people | |||
Key findings
- InflammationImproves (the measure goes down)
The Trismus (Lockjaw/Limited Jaw Opening) Support protocol
2 primary supplements · 6 supporting supplements
- Magnesium400–600 mg daily
- Omega-3 Fatty Acids2–3 g EPA+DHA daily
Studies cited
11 studies from PubMed
- The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial
- A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model
- A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling
- [Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-- a prospective study]
- Comparison of the roles of serratiopeptidase and dexamethasone in the control of inflammation and trismus following impacted third molar surgery
- Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo
- [Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase]
- Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease
- A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome
- Effect of expectorants on relaxation behavior of sputum viscoelasticity in vivo
- The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus