Diosmin
Diosmin is a citrus flavonoid glycoside used for chronic venous insufficiency and hemorrhoids. Typically formulated as micronized purified flavonoid fraction (MPFF; Daflon) containing 90% diosmin and 10% hesperidin. Cochrane meta-analysis (56 RCTs, n=7690): Phlebotonics including diosmin reduced leg edema (RR 0.70) and ankle circumference (-4.27mm) vs placebo. Systematic review for hemorrhoids (22 RCTs, n=2335): MPFF improved post-hemorrhoidectomy outcomes, reduced bleeding rate, pain score, and edema. MPFF is the only venoactive drug recommended in CVD guidelines with Grade 1B evidence. Mechanism involves venous tone improvement, lymphatic drainage enhancement, and microcirculation protection.
Quick Answer
What it is
Diosmin is a citrus flavonoid glycoside used for chronic venous insufficiency and hemorrhoids. Typically formulated as micronized purified flavonoid fraction (MPFF; Daflon) containing 90% diosmin and 10% hesperidin.
Key findings
- Grade A: Leg Edema Reduction (Chronic Venous Insufficiency)
- Grade A: Chronic Venous Insufficiency Symptoms (Chronic Venous Insufficiency)
- Grade A: Hemorrhoid Symptoms (Hemorrhoids)
Safety
- Cochrane meta-analysis: Phlebotonics probably increase adverse events slightly vs placebo (RR 1.14, 95% CI 1.02-1.27).
ℹ️ Quick Facts: Diosmin
Quick Facts: Diosmin
- Best Evidence:Grade A
- Conditions Studied:3
- Research Outcomes:6
- Grade A Findings:3
- Grade B Findings:3
- Key Effect:Chronic Venous Insufficiency
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (10)
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