Gotu Kola

Centella asiatica (Gotu Kola) is a traditional medicine mainly renowned for its cognitive enhancing properties (usually alongside bacopa monnieri) and its ability to regenerate wound healing. It appears effective on both parameters in preclinical evidence, and may also be anti-rheumatic.

Quick Answer

What it is

Centella asiatica (Gotu Kola) is a traditional medicine mainly renowned for its cognitive enhancing properties (usually alongside bacopa monnieri) and its ability to regenerate wound healing. It appears effective on both parameters in preclinical evidence, and may also be anti-rheumatic.

Key findings

  • Grade A: Chronic Venous Insufficiency Signs (Chronic Venous Insufficiency)
  • Grade B: Blood Flow (Diabetic Microangiopathy)
  • Grade C: Alertness (Cognitive Improvement)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Gotu Kola

Quick Facts: Gotu Kola

  • Best Evidence:Grade A
  • Conditions Studied:10
  • Research Outcomes:28
  • Grade A Findings:1
  • Grade B Findings:2
  • Key Effect:Chronic Venous Insufficiency
Outcomes by grade:
A1
B2
C6
D1
10 conditions Β· 28 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
|
A
Chronic Venous Insufficiency Signs
Moderate Improvement
moderate↑Improves
C
Blood Flow
Small Increase
1 study
small↑Improves
?
Leg Edema
↑Worsens
?
Microcirculation
↑Improves
B
Blood Flow
Small Increase
2 studies
small↑Improves
?
Leg Edema
↑Worsens
?
Microcirculation
↑Improves
B
Chronic Venous Insufficiency Signs
Moderate Improvement
moderate↑Improves
?
Leg Edema
↑Worsens
C
Blood Flow
Small Increase
1 study
small↑Improves
?
Chronic Venous Insufficiency Signs
↑Improves
?
Microcirculation
↑Improves
C
Chronic Venous Insufficiency Signs
Moderate Improvement
moderate↑Improves
?
Microcirculation
↑Improves
C
Blood Flow
Small Increase
1 study
small↑Improves
?
Microcirculation
↑Improves
C
Alertness
Small Improvement
1 study
small↑Improves
?
Reaction Time
2 studies
↑Improves
?
Processing Accuracy
↑Improves
?
Subjective Well-Being
1 study
↑Improves
C
Anxiety Symptoms
Small Improvement
small↓Improves
?
Attention
1 study
↑Improves
?
Depression Symptoms
1 study
↓Improves
?
Stress Signs and Symptoms
1 study
↓Improves
D
Heart Rate
No effect
none
?
Subjective Well-Being
1 study
↑Improves
?
Wound Healing
↑Improves
?
Microcirculation
↑Improves

Research Citations (16)

Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs
PMID: 3544968
Flight microangiopathy in medium- to long-distance flights: prevention of edema and microcirculation alterations with total triterpenic fraction of Centella asiatica
PMID: 11666121
Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry
PMID: 11666123
Centella asiatica extract in venous disorders of the lower limbs. Comparative clinico-instrumental studies with a placebo
PMID: 7037273
Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside
PMID: 6896366
The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study
PMID: 7936334
Improvement of capillary permeability in patients with venous hypertension after treatment with TTFCA
PMID: 2389834
Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica
PMID: 18191355
A clinical study on the management of generalized anxiety disorder with Centella asiatica
PMID: 20677602
Total triterpenic fraction of Centella asiatica in the treatment of venous hypertension: a clinical, prospective, randomized trial using a combined microcirculatory model
PMID: 11666126

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