Condition
Venous Hypertension
Venous hypertension is abnormally high pressure in the leg veins, usually because faulty valves let blood flow backward and pool in the legs, a pattern known as chronic venous insufficiency. Horse chestnut extract and diosmin/hesperidin are the two supplements with the strongest evidence behind them for this condition. Little research on either has been reviewed here so far, though, so there are no trial findings to report yet, and the other supplements people try have less support still.
- Supplements studied
- 1
- Graded outcomes
- 0
- Trials
- 1
- People studied
- 62
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Microcirculation | Improves (the measure goes up) | 3 studies | 62 people | |||
Studies that measured microcirculation
| ||||||
The Venous Hypertension (Chronic Venous Insufficiency) Support protocol
2 primary supplements · 5 supporting supplements
- Horse Chestnut Extract300 mg standardized extract (50 mg aescin) twice daily
- Diosmin/Hesperidin (MPFF)500 mg diosmin/50 mg hesperidin twice daily
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Studies cited
16 studies from PubMed
- Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs
- Flight microangiopathy in medium- to long-distance flights: prevention of edema and microcirculation alterations with total triterpenic fraction of Centella asiatica
- Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry
- Centella asiatica extract in venous disorders of the lower limbs. Comparative clinico-instrumental studies with a placebo
- Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside
- The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study
- Improvement of capillary permeability in patients with venous hypertension after treatment with TTFCA
- Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica
- A clinical study on the management of generalized anxiety disorder with Centella asiatica
- Total triterpenic fraction of Centella asiatica in the treatment of venous hypertension: a clinical, prospective, randomized trial using a combined microcirculatory model
- Effects of the total triterpenic fraction of Centella asiatica in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial
- Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: a clinical, prospective, placebo-controlled, randomized, dose-ranging trial
- Treatment of diabetic microangiopathy and edema with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled randomized study
- Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model
- The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients
- A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects