Dr. Grey AI

Haninjin

Artemisia iwayomogi (Haninjin) is a Korean herb in the mugwort/wormwood family with limited traditional use but emerging preclinical research. NO GRADED OUTCOMES - only animal and in vitro studies exist. May have anti-allergic, anti-obesity (PPARδ activation), and anti-cancer properties based on preliminary research. Contains sesquiterpenes, flavonoids, and coumarins. NOT to be confused with other Artemisia species (A. annua for malaria, A. absinthium for absinthe). Human evidence is completely lacking - research is too preliminary for any recommendations.

Quick Answer

What it is

Artemisia iwayomogi (Haninjin) is a Korean herb in the mugwort/wormwood family with limited traditional use but emerging preclinical research. NO GRADED OUTCOMES - only animal and in vitro studies exist.

Key findings

  • Grade D: Allergic Response
  • Grade D: Fat Mass
  • Grade D: Liver Fibrosis

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Haninjin

Quick Facts: Haninjin

  • Best Evidence:Grade D
  • Conditions Studied:5
  • Research Outcomes:7
  • Key Effect:Allergic Diseases (General)
Outcomes by grade:
A0
B0
C0
D7
5 conditions · 7 outcomes

Detailed Outcomes

Grade:
Effect:
Size:
Sort:
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D
Allergic Response
In rodent models, Artemisia iwayomogi extract dose-dependently inhibited systemic anaphylactic reactions (compound 48/80-induced in ICR mice), passive cutaneous anaphylaxis (Sprague-Dawley rats), and ovalbumin-induced allergic airway inflammation (BALB/c mice). Mechanisms include mast cell stabilization via NF-kappaB/p38 MAPK inhibition, reduced histamine release, and suppression of Th2 cytokines and serum IgE. No human studies exist.
moderate↓Improves
D
Fat Mass
Three independent mouse studies showed A. iwayomogi extract attenuated high-fat diet-induced obesity. The extract acts as a direct PPARdelta ligand activating skeletal muscle fatty acid oxidation (n=9/group), suppresses adipogenic transcription factors PPARgamma2/C/EBPalpha reducing visceral adiposity and insulin resistance (n=10/group), and dose-dependently improves hypertriglyceridemia via adiponectin-AMPK pathway activation (n=8/group). All evidence is preclinical.
moderate↓Improves
D
Liver Fibrosis
In rat models of CCl4-induced hepatic fibrosis and bile duct ligation cholestasis, A. iwayomogi at 25-50 mg/kg significantly reduced serum ALT/AST, hepatic collagen accumulation, and fibrogenic markers (TGF-beta, PDGF, alpha-SMA). Mechanisms involve enhanced antioxidant capacity (glutathione, SOD) and hepatic stellate cell deactivation. Notably, A. capillaris showed no benefit in the same CCl4 model. No human data.
moderate↓Improves
D
Cancer Cell Proliferation
In vitro, essential oil from A. iwayomogi induced apoptosis in KB human oral epidermoid carcinoma cells via MAPK-mediated mitochondrial dysfunction and caspase activation. A polysaccharide fraction (AIP1) showed immunomodulatory activity suppressing thymocyte apoptosis, with earlier reports of transplanted tumor growth suppression in mice. Evidence is limited to cell culture with no in vivo tumor studies using the whole extract.
small↓Worsens
D
Neuroinflammation
In 5xFAD transgenic Alzheimer's mice, A. iwayomogi extract improved cognitive function in Morris Water Maze tests, reduced amyloid-beta burden, and suppressed glial overactivation via AKT/autophagy-lysosomal pathways (n=12-18/group). Separately, the isolated compound yomogin (5 mg/kg) suppressed LPS-induced neuroinflammation in mice by inhibiting JNK/ERK/p38 MAPK phosphorylation (n=5/group). All preclinical.
small↓Improves
D
Asthma Symptoms
In an ovalbumin-induced allergic asthma model in BALB/c mice, the carbohydrate fraction AIP1 from A. iwayomogi significantly reduced pulmonary eosinophilia, Th2-type cytokine expression, serum IgE levels, and TNF-alpha expression. The mechanism involved decreased dendritic cell surface expression of CD11c and MHC II. Single preclinical study only.
small↓Improves
D
Bone Resorption
In vitro, scopoletin and scopolin (coumarins isolated from A. iwayomogi) suppressed RANKL-induced osteoclast differentiation in RAW 264.7 macrophage cells by scavenging intracellular ROS and superoxide anions during osteoclastogenesis. Single in vitro study with no animal or human follow-up.
small↓Improves

Research Citations (18)

Artemisia iwayomogi herbal extract improves learning and reduces amyloid-beta burden in 5xFAD Alzheimer's disease mice
(2024)
PMID: 39433702
Development of real-time PCR based molecular markers for two medicinal herb Artemisia species A. capillaris and A. iwayomogi
(2023)
PMID: 36606092
Yomogin from Artemisia iwayomogi suppresses neuroinflammatory responses via MAPK inhibition
(2022)
PMID: 36670968
Polyphenolic extract from Artemisia iwayomogi flowers inhibits NF-kappaB signaling in LPS-stimulated macrophages
(2020)
PMID: 32104280
Artemisia iwayomogi extract attenuates high-fat diet-induced hypertriglyceridemia in mice: potential involvement of the adiponectin-AMPK pathway and very low density lipoprotein assembly in the liver
(2017)
PMID: 28805698
Artemisia iwayomogi extract attenuates high-fat diet-induced obesity by decreasing the expression of genes associated with adipogenesis in mice
(2013)
PMID: 23401719
Scopoletin and scopolin from Artemisia iwayomogi suppress RANKL-induced osteoclast differentiation
(2013)
PMID: 23510022
An ethanol extract of Artemisia iwayomogi activates PPARdelta leading to activation of fatty acid oxidation in skeletal muscle
(2012)
PMID: 22479450
Artemisia iwayomogi aqueous extract attenuates hepatic steatosis, fibrosis, and inflammation in a rat model of chronic liver injury
(2012)
PMID: 22265746
Aqueous extract of Artemisia iwayomogi attenuates cholestatic liver fibrosis in a rat model
(2012)
PMID: 22824087

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