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Haninjin

Haninjin is an extract of Artemisia iwayomogi, a Korean medicinal herb whose plant compounds, including coumarins and polysaccharides, appear to calm inflammatory signaling in cells. The best-studied area is allergic response, where rodent studies found the extract dampened anaphylactic reactions and allergic airway inflammation, partly by steadying mast cells that release histamine. Nearly all the work so far was in mice, rats, or cell cultures, so the evidence is very limited and says little yet about people.

Sources: PMID 15618130; PMID 16997791

Best evidence
Grade D
Conditions studied
5
Outcomes
7
Graded outcomes
0007

Evidence by condition

  • Strong
  • Moderate
  • Limited
  • Very limited

5 conditions, plus general outcomes

Allergic Diseases (General)

Allergic Diseases (General): outcomes studied for Haninjin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Allergic Response

In rodent models, Artemisia iwayomogi extract dose-dependently inhibited systemic anaphylactic reactions (compound 48/80-induced in ICR mice), passive cutaneous anaphylaxis (Sprague-Dawley rats), and ovalbumin-induced allergic airway inflammation (BALB/c mice). Mechanisms include mast cell stabilization via NF-kappaB/p38 MAPK inhibition, reduced histamine release, and suppression of Th2 cytokines and serum IgE. No human studies exist.

Improves (the measure goes down)Moderate effect7 studies

Studies that measured allergic response

Body Composition

Body Composition: outcomes studied for Haninjin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Fat Mass

Three independent mouse studies showed A. iwayomogi extract attenuated high-fat diet-induced obesity. The extract acts as a direct PPARdelta ligand activating skeletal muscle fatty acid oxidation (n=9/group), suppresses adipogenic transcription factors PPARgamma2/C/EBPalpha reducing visceral adiposity and insulin resistance (n=10/group), and dose-dependently improves hypertriglyceridemia via adiponectin-AMPK pathway activation (n=8/group). All evidence is preclinical.

Improves (the measure goes down)Moderate effect7 studies

Studies that measured fat mass

General

  • Liver Fibrosis: improves
  • Cancer Cell Proliferation: changes; see studies
General: outcomes studied for Haninjin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Liver Fibrosis

In rat models of CCl4-induced hepatic fibrosis and bile duct ligation cholestasis, A. iwayomogi at 25-50 mg/kg significantly reduced serum ALT/AST, hepatic collagen accumulation, and fibrogenic markers (TGF-beta, PDGF, alpha-SMA). Mechanisms involve enhanced antioxidant capacity (glutathione, SOD) and hepatic stellate cell deactivation. Notably, A. capillaris showed no benefit in the same CCl4 model. No human data.

Improves (the measure goes down)Moderate effect7 studies

Studies that measured liver fibrosis

Cancer Cell Proliferation

In vitro, essential oil from A. iwayomogi induced apoptosis in KB human oral epidermoid carcinoma cells via MAPK-mediated mitochondrial dysfunction and caspase activation. A polysaccharide fraction (AIP1) showed immunomodulatory activity suppressing thymocyte apoptosis, with earlier reports of transplanted tumor growth suppression in mice. Evidence is limited to cell culture with no in vivo tumor studies using the whole extract.

Changes; see studiesSmall effect6 studies

Studies that measured cancer cell proliferation

Alzheimer’s Disease

  • Neuroinflammation: improves
Alzheimer’s Disease: outcomes studied for Haninjin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Neuroinflammation

In 5xFAD transgenic Alzheimer's mice, A. iwayomogi extract improved cognitive function in Morris Water Maze tests, reduced amyloid-beta burden, and suppressed glial overactivation via AKT/autophagy-lysosomal pathways (n=12-18/group). Separately, the isolated compound yomogin (5 mg/kg) suppressed LPS-induced neuroinflammation in mice by inhibiting JNK/ERK/p38 MAPK phosphorylation (n=5/group). All preclinical.

Improves (the measure goes down)Small effect6 studies

Studies that measured neuroinflammation

Asthma

  • Asthma Symptoms: improves
Asthma: outcomes studied for Haninjin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Asthma Symptoms

In an ovalbumin-induced allergic asthma model in BALB/c mice, the carbohydrate fraction AIP1 from A. iwayomogi significantly reduced pulmonary eosinophilia, Th2-type cytokine expression, serum IgE levels, and TNF-alpha expression. The mechanism involved decreased dendritic cell surface expression of CD11c and MHC II. Single preclinical study only.

Improves (the measure goes down)Small effect5 studies

Studies that measured asthma symptoms

Bone Health

  • Bone Resorption: improves
Bone Health: outcomes studied for Haninjin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Bone Resorption

In vitro, scopoletin and scopolin (coumarins isolated from A. iwayomogi) suppressed RANKL-induced osteoclast differentiation in RAW 264.7 macrophage cells by scavenging intracellular ROS and superoxide anions during osteoclastogenesis. Single in vitro study with no animal or human follow-up.

Improves (the measure goes down)Small effect5 studies

Studies that measured bone resorption

Key findings

  • Allergic ResponseAllergic Diseases (General)Improves (the measure goes down)
  • Fat MassBody CompositionImproves (the measure goes down)
  • Liver FibrosisImproves (the measure goes down)

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Third-party tested Haninjin products. The evidence above is limited, so read it before you buy.

  • Grade D

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Studies cited

18 studies from PubMed

  1. Artemisia iwayomogi herbal extract improves learning and reduces amyloid-beta burden in 5xFAD Alzheimer's disease miceGeroScience, 2024 · PMID 39433702
  2. Development of real-time PCR based molecular markers for two medicinal herb Artemisia species A. capillaris and A. iwayomogiFood Science and Biotechnology, 2023 · PMID 36606092
  3. Yomogin from Artemisia iwayomogi suppresses neuroinflammatory responses via MAPK inhibitionAntioxidants, 2022 · PMID 36670968
  4. Polyphenolic extract from Artemisia iwayomogi flowers inhibits NF-kappaB signaling in LPS-stimulated macrophagesExperimental and Therapeutic Medicine, 2020 · PMID 32104280
  5. Artemisia iwayomogi extract attenuates high-fat diet-induced hypertriglyceridemia in mice: potential involvement of the adiponectin-AMPK pathway and very low density lipoprotein assembly in the liverInternational Journal of Molecular Sciences, 2017 · PMID 28805698
  6. Artemisia iwayomogi extract attenuates high-fat diet-induced obesity by decreasing the expression of genes associated with adipogenesis in miceEvidence-Based Complementary and Alternative Medicine, 2013 · PMID 23401719
  7. Scopoletin and scopolin from Artemisia iwayomogi suppress RANKL-induced osteoclast differentiationJournal of Natural Products, 2013 · PMID 23510022
  8. An ethanol extract of Artemisia iwayomogi activates PPARdelta leading to activation of fatty acid oxidation in skeletal musclePLoS One, 2012 · PMID 22479450
  9. Artemisia iwayomogi aqueous extract attenuates hepatic steatosis, fibrosis, and inflammation in a rat model of chronic liver injuryJournal of Ethnopharmacology, 2012 · PMID 22265746
  10. Aqueous extract of Artemisia iwayomogi attenuates cholestatic liver fibrosis in a rat modelFood and Chemical Toxicology, 2012 · PMID 22824087
  11. Essential oil of Artemisia iwayomogi induces apoptosis in KB cells via mitochondrial dysfunction and MAPK activationJournal of Ethnopharmacology, 2009 · PMID 19429377
  12. A carbohydrate fraction AIP1 from Artemisia iwayomogi suppresses pulmonary eosinophilia and Th2-type cytokine production in an ovalbumin-induced allergic asthma modelInternational Immunopharmacology, 2008 · PMID 18068107
  13. Application of the multiplex PCR method for discrimination of Artemisia iwayomogi from other Artemisia herbsBiological & Pharmaceutical Bulletin, 2008 · PMID 18379063
  14. Inhibitory effect of Artemisia iwayomogi on immediate-type allergic reactionImmunopharmacology and Immunotoxicology, 2006 · PMID 16997791
  15. Development of SCAR marker for discrimination of Artemisia princeps and A. argyi from other Artemisia herbsBiological & Pharmaceutical Bulletin, 2006 · PMID 16595892
  16. Anti-allergic effect of Artemisia iwayomogi on mast cell-mediated anaphylaxisExperimental Biology and Medicine, 2005 · PMID 15618130
  17. AIP1 from Artemisia iwayomogi suppresses thymocyte apoptosis via Fas/FasL pathway modulationBiological & Pharmaceutical Bulletin, 2005 · PMID 15863908
  18. Inhibition of CCl4-induced liver fibrosis by Artemisia iwayomogiNot specified, 2000 · PMID 10933139