Condition
Allergic Diseases (General)
Allergic diseases arise when the immune system overreacts to harmless things like pollen, dust mites, or foods, releasing histamine and other chemicals that cause sneezing, itching, and swelling. Probiotics are among the best-supported supplements, with moderate evidence, and trials of one strain, Lactobacillus acidophilus L-92, found eczema symptoms eased in children and adults. Those studies were small, though, and most plant extracts have only been tested in animals or cells.
Sources: PMID 20861645; PMID 25660281
- Supplements studied
- 7
- Graded outcomes
- 7
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Atopic Dermatitis Symptoms Three clinical trials using the L. acidophilus L-92 strain demonstrated improvements in atopic dermatitis symptoms. A double-blind RCT in Japanese adults and a pediatric study both showed reductions in dermatitis severity scores and serum cytokine markers. A third trial demonstrated efficacy with prolonged ingestion of L-92 in adult patients. | Improves (the measure goes down) | Small effect | 4 studies | 250 people | ||
Studies that measured atopic dermatitis symptoms
| ||||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Allergic Response In rodent models, Artemisia iwayomogi extract dose-dependently inhibited systemic anaphylactic reactions (compound 48/80-induced in ICR mice), passive cutaneous anaphylaxis (Sprague-Dawley rats), and ovalbumin-induced allergic airway inflammation (BALB/c mice). Mechanisms include mast cell stabilization via NF-kappaB/p38 MAPK inhibition, reduced histamine release, and suppression of Th2 cytokines and serum IgE. No human studies exist. | Improves (the measure goes down) | Moderate effect | 7 studies | |||
Studies that measured allergic response
| ||||||
Chinese Hawthorn
- Allergic Inflammation: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Allergic Inflammation Preclinical studies report that Chinese hawthorn extracts inhibit mast cell degranulation and histamine release, and reduce inflammatory cytokines via NF-κB inhibition. Evidence is limited to in vitro and animal models with no human trials. | Improves (the measure goes down) | Small effect | 3 studies | |||
Studies that measured allergic inflammation | ||||||
Japanese catnip
- Allergic Response: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Allergic Response In IgE-stimulated RBL-2H3 mast cells, S. tenuifolia suppressed degranulation (beta-hexosaminidase release) and reduced IFN-gamma, TNF-alpha, IL-4, and IL-6 at 100 mcg/mL. In rats, the extract dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and reduced plasma histamine levels. In a DNCB-induced atopic dermatitis mouse model, treatment suppressed serum IgE, TNF-alpha, and IL-6, and downregulated NF-kappaB and MAPK expression. No human data exists. | Improves (the measure goes down) | Moderate effect | 3 studies | |||
Studies that measured allergic response | ||||||
East Indian globe thistle
- Mast Cell Stabilization (Anti-allergic): changes; see studies
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Mast Cell Stabilization (Anti-allergic) In an animal/in vitro study, ethanol and ethyl acetate extracts of S. indicus showed 77–88% protection against mast cell degranulation induced by compound 48/80 and sheep serum, slightly exceeding the standard drug ketotifen (69–75%). Suggests potent mast cell stabilizing activity comparable to established anti-allergic agents. | Changes; see studies | Moderate effect | 2 studies | |||
Studies that measured mast cell stabilization (anti-allergic) | ||||||
Lactosucrose
- Allergic IgE Response: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Allergic IgE Response In OVA-sensitized mice, dietary lactosucrose supplementation produced dose-dependent suppression of anti-ovalbumin IgE responses. Lactosucrose inhibited antigen-specific IgE and IgG1 production even after a second immunization, while splenocytes showed reduced IL-4 and IL-5 production and augmented IL-10 production, suggesting a Th1/Th2 rebalancing effect. No human data available. | Improves (the measure goes down) | Moderate effect | 1 study | |||
Studies that measured allergic ige response | ||||||
Histidine
- Atopic Dermatitis Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Atopic Dermatitis Symptoms Limited human studies have explored histidine supplementation in atopic dermatitis, potentially related to its role in filaggrin production (a histidine-rich protein important for skin barrier function). Evidence is preliminary and insufficient for clinical recommendations. | Improves (the measure goes down) | Small effect |
Key findings
- Atopic Dermatitis SymptomsImproves (the measure goes down)
- Allergic ResponseImproves (the measure goes down)
- Allergic InflammationImproves (the measure goes down)
The Allergic Diseases General Support protocol
2 primary supplements · 7 supporting supplements
- Quercetin500–1,000 mg daily in divided doses
- Probiotics10–20 billion CFU multi-strain daily (Lactobacillus and Bifidobacterium strains)
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- Grade B
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Studies cited
76 studies from PubMed
- The active components of the Danshen-Shanzha herb-pair exert a protective effect on MASLD by synergistically promoting fatty acid oxidation via the activation of PPARα, Plin-5 and Plin-2.
- Phytochemical and nanoparticle-based therapeutic potential of Sphaeranthus indicus against hepatocellular carcinoma via cryptomeridiol targeting
- A botanical extract blend of Mangifera indica and Sphaeranthus indicus combined with resistance exercise training improves muscle strength and endurance over exercise alone in young men: a randomized, blinded, placebo-controlled trial
- Artemisia iwayomogi herbal extract improves learning and reduces amyloid-beta burden in 5xFAD Alzheimer's disease mice
- Crataegus pinnatifida: A botanical, ethnopharmacological, phytochemical, and pharmacological overview.
- Rapid determination of chemical components and antioxidant activity of the fruit of Crataegus pinnatifida Bunge by NIRS and chemometrics.
- A proprietary blend of Sphaeranthus indicus flower head and Mangifera indica bark extracts increases muscle strength and enhances endurance in young male volunteers: a randomized, double-blinded, placebo-controlled trial
- Development of real-time PCR based molecular markers for two medicinal herb Artemisia species A. capillaris and A. iwayomogi
- Protective effect of Schizonepeta tenuifolia Briq. ethanolic extract against UVB-induced skin aging and photodamage in hairless mice
- Yomogin from Artemisia iwayomogi suppresses neuroinflammatory responses via MAPK inhibition
- Effects of 4G-beta-D-Galactosylsucrose in patients with depression: A randomized, double-blinded, placebo-controlled, parallel-group comparative study.
- Spectrum-effect relationship between GC-QTOF-MS fingerprint and antioxidant, anti-inflammatory activities of Schizonepeta tenuifolia essential oil
- Potential benefits of L. acidophilus in dyslipidemic rats
- Effect of a Probiotic Supplement Containing Lactobacillus Acidophilus and Bifidobacterium Animalis Lactis on Urine Oxalate in Calcium Stone Formers with Hyperoxaluria: A Randomized, Placebo-controlled, Double-blind and In-vitro Trial
- Polyphenolic extract from Artemisia iwayomogi flowers inhibits NF-kappaB signaling in LPS-stimulated macrophages
- Preventive Effect of Lactobacillus acidophilus XY27 on DSS-Induced Ulcerative Colitis in Mice
- Immune enhancing effects of Lactobacillus acidophilus on Newcastle disease vaccination in chickens
- Lactobacillus acidophilus attenuates toxin production by Vibrio cholerae and shigella dysenteriae following intestinal epithelial cells infection
- Effects and mechanisms of Danshen-Shanzha herb-pair for atherosclerosis treatment using network pharmacology and experimental pharmacology.
- 7-hydroxyfrullanolide, isolated from Sphaeranthus indicus, inhibits colorectal cancer cell growth by p53-dependent and -independent mechanism
- Schizonepeta tenuifolia inhibits collagen stimulated platelet function via suppressing MAPK and Akt signaling
- Immunomodulation Effects of Schizonepeta tenuifolia Briq. on the IgE-Induced Allergic Model of RBL-2H3 Cells
- Primary prevention of Clostridium difficile infections with a specific probiotic combining Lactobacillus acidophilus, L. casei, and L. rhamnosus strains: assessing the evidence
- Lactobacillus acidophilus Alleviated Salmonella-Induced Goblet Cells Loss and Colitis by Notch Pathway
- Lactobacillus acidophilus ameliorates pain and cartilage degradation in experimental osteoarthritis
- Artemisia iwayomogi extract attenuates high-fat diet-induced hypertriglyceridemia in mice: potential involvement of the adiponectin-AMPK pathway and very low density lipoprotein assembly in the liver
- Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: An open randomized controlled trial
- Uromodulin-SlpA binding dictates Lactobacillus acidophilus uptake by intestinal epithelial M cells
- Ethanol extract of Zhongtian hawthorn lowers serum cholesterol in mice by inhibiting transcription of 3-hydroxy-3-methylglutaryl-CoA reductase via nuclear factor-kappa B signal pathway.
- Lactobacillus acidophilus Mixture in Treatment of Children Hospitalized With Acute Diarrhea
- Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis
- Lactobacillus acidophilus attenuates Salmonella-induced intestinal inflammation via TGF-β signaling
- The effects of Lactobacillus acidophilus as feed supplement on skin mucosal immune parameters, intestinal microbiota, stress resistance and growth performance of black swordtail
- Lactobacillus acidophilus CP23 with weak immunomodulatory activity lacks anchoring structure for surface layer protein
- Crataegus pinnatifida: Chemical constituents, pharmacology, and potential applications
- Sphaeranthus indicus (East Indian Globe Thistle) - A promising natural remedy for psoriasis
- Schizonepeta tenuifolia ethanol extract exerts anti-inflammatory activity through the inhibition of TLR4 signaling in lipopolysaccharide-stimulated macrophage cells
- Lactobacillus acidophilus modulates the virulence of Clostridium difficile
- Effects of oral administration of Lactobacillus acidophilus L-92 on the symptoms and serum cytokines of atopic dermatitis in Japanese adults: a double-blind, randomized, clinical trial
- Antioxidant activity and components of a traditional Chinese medicine formula consisting of Crataegus pinnatifida and Salvia miltiorrhiza.
- Sphaeranthus indicus induces apoptosis through mitochondrial-dependent pathway in HL-60 cells and exerts cytotoxic potential on several human cancer cell lines
- Artemisia iwayomogi extract attenuates high-fat diet-induced obesity by decreasing the expression of genes associated with adipogenesis in mice
- Scopoletin and scopolin from Artemisia iwayomogi suppress RANKL-induced osteoclast differentiation
- Schizonepeta tenuifolia inhibits the development of atopic dermatitis in mice
- Effect of Sphaeranthus indicus on cisplatin-induced nephrotoxicity in rats
- Effect of ethanol extract of Sphaeranthus indicus on cisplatin-induced nephrotoxicity in rats
- An ethanol extract of Artemisia iwayomogi activates PPARdelta leading to activation of fatty acid oxidation in skeletal muscle
- Artemisia iwayomogi aqueous extract attenuates hepatic steatosis, fibrosis, and inflammation in a rat model of chronic liver injury
- Aqueous extract of Artemisia iwayomogi attenuates cholestatic liver fibrosis in a rat model
- Antioxidant and anti-inflammatory activities of aqueous extracts of Schizonepeta tenuifolia Briq
- Decrease of blood lipids induced by Shan-Zha (fruit of Crataegus pinnatifida) is mainly related to an increase of PPARα in liver of mice fed high-fat diet.
- Development of the origin and application of shanza in ancient and modern.
- Sphaeranthus indicus attenuates testosterone induced prostatic hypertrophy in albino rats
- Effects of oral administration of Lactobacillus acidophilus L-92 on the symptoms and serum markers of atopic dermatitis in children
- Sphaeranthus indicus Linn.: A phytopharmacological review
- Probiotic Lactobacillus acidophilus and L. casei mix sensitize colorectal tumoral cells to 5-fluorouracil-induced apoptosis
- Mast cell stabilizing effects of Sphaeranthus indicus
- Essential oil of Artemisia iwayomogi induces apoptosis in KB cells via mitochondrial dysfunction and MAPK activation
- A carbohydrate fraction AIP1 from Artemisia iwayomogi suppresses pulmonary eosinophilia and Th2-type cytokine production in an ovalbumin-induced allergic asthma model
- Application of the multiplex PCR method for discrimination of Artemisia iwayomogi from other Artemisia herbs
- Anti-inflammatory activity of Schizonepeta tenuifolia through the inhibition of MAPK phosphorylation in mouse peritoneal macrophages
- Anti-inflammatory and anti-allergic activities of Crataegus pinnatifida
- Cytotoxic activity of Sphaeranthus indicus extracts and 7-hydroxyfrullanolide
- Effects of dietary lactosucrose (4G-beta-D-galactosylsucrose) on the IgE response in mice.
- Inhibitory effect of Artemisia iwayomogi on immediate-type allergic reaction
- Development of SCAR marker for discrimination of Artemisia princeps and A. argyi from other Artemisia herbs
- Long-term administration of 4G-beta-D-galactosylsucrose (lactosucrose) enhances intestinal calcium absorption in young women: a randomized, placebo-controlled 96-wk study.
- Anti-allergic effect of Artemisia iwayomogi on mast cell-mediated anaphylaxis
- AIP1 from Artemisia iwayomogi suppresses thymocyte apoptosis via Fas/FasL pathway modulation
- Effect of Crataegus pinnatifida extract on blood lipids and antioxidant activity in hyperlipidemic rats
- Inhibition of CCl4-induced liver fibrosis by Artemisia iwayomogi
- Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type hypersensitivity in rats
- Effect of 4G-beta-D-galactosylsucrose (lactosucrose) on fecal microflora in patients with chronic inflammatory bowel disease.
- Effects of dietary supplementation with lactosucrose (4G-beta-D-galactosylsucrose) on cecal flora, cecal metabolites, and performance in broiler chickens.
- Effect of lactosucrose (4G-beta-D-galactosylsucrose) on fecal flora and fecal putrefactive products of cats.
- Transmission of Lactobacillus jensenii and Lactobacillus acidophilus from mother to child at time of delivery