Supplement
Chlorogenic acid is a natural plant compound, found in coffee beans and some fruits and vegetables, that acts as an antioxidant in the body. People mostly look at it for blood pressure, and a small trial in people with high blood pressure found their readings improved, though the evidence is limited. That rests on a single study of 28 people, and a review of cognition across 243 participants found no clear difference.
Sources: PMID 16820341
- Updated
- How we grade
- 4 studies cited
- Best evidence
- Grade C
- Conditions studied
- 6
- Outcomes
- 11
- Graded outcomes
- 0042
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Subjective Well-Being Small Improvement | Improves (the measure goes up) | Small effect | 1 study | 39 people | ||
Studies that measured subjective well-being | ||||||
| Cognition No effect | NoneNo effect | 1 study | 243 people | |||
Studies that measured cognition | ||||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood Pressure Moderate Improvement | Improves (the measure goes down) | Moderate effect | 1 study | 28 people | ||
Studies that measured blood pressure | ||||||
| Weight | Improves (the measure goes down) | 1 study | 28 people | |||
Obesity
- Blood glucose: improves
- Insulin: changes; see studies
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood glucose Small Improvement | Improves (the measure goes down) | Small effect | 15 people | |||
| Insulin | Changes; see studies | 1 study | 15 people | |||
Metabolic Health
- Glycemic Control: improves
- Weight: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Glycemic Control Small Improvement | Improves (the measure goes up) | Small effect | 30 people | |||
| Weight | Improves (the measure goes down) | 1 study | 30 people | |||
Mood Improvement
- Cognition
- Subjective Well-Being: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cognition No effect | NoneNo effect | 1 study | 39 people | |||
Studies that measured cognition | ||||||
| Subjective Well-Being | Improves (the measure goes up) | 1 study | 39 people | |||
Studies that measured subjective well-being | ||||||
General Cardiovascular Health
- Homocysteine: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Homocysteine | Improves (the measure goes down) | 1 study | 20 people | |||
Key findings
- Subjective Well-BeingImproves (the measure goes up)
- Blood PressureImproves (the measure goes down)
- Blood glucoseImproves (the measure goes down)
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Third-party tested Chlorogenic Acid products. The evidence above is limited, so read it before you buy.
- Grade C
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Studies cited
4 studies from PubMed
- Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance
- Does coffee enriched with chlorogenic acids improve mood and cognition after acute administration in healthy elderly? A pilot study
- Impact of coffee-derived chlorogenic acid on cognition: a systematic review and meta-analysis.
- Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans