Chitosan

Chitosan is a fiber derived from chitin in crustacean shells (shrimp, crab, lobster) or fungi. Marketed as a 'fat blocker' for weight loss due to its ability to bind dietary fat in the GI tract. Meta-analyses of RCTs show modest weight loss (1-2kg) and cholesterol reduction, but effects are smaller than often claimed. Does NOT selectively block fat - binds bile acids and some minerals too. Generally considered safe but effect size is clinically minimal compared to lifestyle interventions.

Quick Answer

What it is

Chitosan is a fiber derived from chitin in crustacean shells (shrimp, crab, lobster) or fungi. Marketed as a 'fat blocker' for weight loss due to its ability to bind dietary fat in the GI tract.

Key findings

Grade C: Body Weight (Obesity)
Grade C: Total Cholesterol (High Cholesterol)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Chitosan

Quick Facts: Chitosan

Best Evidence:Grade C
Conditions Studied:2
Research Outcomes:2
Key Effect:Obesity

Outcomes by grade:

2 conditions · 2 outcomes

Detailed Outcomes

Body Weight

Meta-analyses: Weight loss of 1.7-2kg more than placebo over 4-24 weeks. Effect is statistically significant but clinically modest.

15 studies1200 participants

small↓Improves

Total Cholesterol

Meta-analysis: Modest reduction in total cholesterol (5-8%) and LDL. Mechanism via bile acid binding.

12 studies800 participants

small↓Improves

Evidence by Condition

Best grade per condition (each condition may have multiple outcomes)

CObesity

1 outcome · 15 studies

↓Body WeightImproves

CHigh Cholesterol

1 outcome · 12 studies

↓Total CholesterolImproves

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