Peptide
BPC-157
BPC-157 is a synthetic 15-amino-acid peptide derived from human gastric juice proteins. B-GRADE for tendon healing (6 studies, 180 participants) and gastric ulcer healing (8 studies, 240 participants). C-GRADE for ligament healing, muscle recovery, wound healing, and neuroprotection. CRITICAL CAVEAT: Nearly all evidence is from ANIMAL studies - human clinical trials are extremely limited. Popular in biohacking/sports communities but regulatory status unclear. NOT FDA-approved. Underground/gray market sourcing raises purity and safety concerns.
- Updated
- How we grade
- 69 studies cited
Research notice. This page is for education and research. Peptides may not be FDA-approved for human use and may only be legally available for research. Talk to a qualified clinician before considering any peptide.
- Best evidence
- Grade C
- Conditions studied
- 5
- Outcomes
- 15
- Graded outcomes
- 00105
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
Skin Health
- Wound Healing Rate: improves
Neurological Health
- Neuroprotection: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Neuroprotection Moderate Protection (mostly animal data) | Improves (the measure goes up) | Moderate effect | 7 studies | 75 people | ||
Studies that measured neuroprotection
| ||||||
General
- Angiogenesis: improves
- Anti-Aging: improves
- Corneal/Ocular Health: improves
Cardiovascular Health
- Endothelial Function: improves
Key findings
- Gastric Ulcer HealingImproves (the measure goes up)
- Tendon HealingImproves (the measure goes up)
- Ligament HealingImproves (the measure goes up)
Studies cited
69 studies from PubMed
- BPC 157 Therapy: Targeting Angiogenesis and Nitric Oxide's Cytotoxic and Damaging Actions, but Maintaining, Promoting, or Recovering Their Essential Protective Functions. Comment on Józwiak et al. Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review. Pharmaceuticals 2025, 18, 185.
- Protective Effects of BPC 157 on Liver, Kidney, and Lung Distant Organ Damage in Rats with Experimental Lower-Extremity Ischemia-Reperfusion Injury.
- Acute Compartment Syndrome and Intra-Abdominal Hypertension, Decompression, Current Pharmacotherapy, and Stable Gastric Pentadecapeptide BPC 157 Solution.
- Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study.
- Stable Gastric Pentadecapeptide BPC 157 as a Therapy and Safety Key: A Special Beneficial Pleiotropic Effect Controlling and Modulating Angiogenesis and the NO-System.
- Concerning BPC-157, a natural pentadecapeptide, that acts as a cytoprotectant and is believed to protect the gastro-intestinal tract (GIT).
- Injectable Therapeutic Peptides-An Adjunct to Regenerative Medicine and Sports Performance?
- Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing.
- Stable Gastric Pentadecapeptide BPC 157 as Therapy After Surgical Detachment of the Quadriceps Muscle from Its Attachments for Muscle-to-Bone Reattachment in Rats.
- Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review.
- Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.
- Protective effect of resveratrol on nickel-refining fumes-induced inflammatory damage.
- Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats-A Review.
- Stable Gastric Pentadecapeptide BPC 157 Therapy: Effect on Reperfusion Following Maintained Intra-Abdominal Hypertension (Grade III and IV) in Rats.
- Stable Gastric Pentadecapeptide BPC 157 May Recover Brain-Gut Axis and Gut-Brain Axis Function.
- Stable Gastric Pentadecapeptide BPC 157-Possible Novel Therapy of Glaucoma and Other Ocular Conditions.
- Antiarrhythmic Sotalol, Occlusion/Occlusion-like Syndrome in Rats, and Stable Gastric Pentadecapeptide BPC 157 Therapy.
- Pentadecapeptide BPC 157 and the central nervous system
- Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats.
- Pentadecapeptide BPC 157 efficiently reduces radiation-induced liver injury and lipid accumulation through Kruppel-like factor 4 upregulation both in vivo and in vitro.
- Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation.
- Cytoprotective gastric pentadecapeptide BPC 157 resolves major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome.
- Fourier Transform Infrared Spectroscopy Reveals Molecular Changes in Blood Vessels of Rats Treated with Pentadecapeptide BPC 157.
- Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle.
- The anti-nociceptive effect of BPC-157 on the incisional pain model in rats.
- Stable Gastric Pentadecapeptide BPC 157 and Wound Healing
- Stable Gastric Pentadecapeptide BPC 157 Therapy for Monocrotaline-Induced Pulmonary Hypertension in Rats Leads to Prevention and Reversal.
- Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157.
- BPC 157 as a Therapy for Retinal Ischemia Induced by Retrobulbar Application of L-NAME in Rats.
- Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain.
- Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway
- The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats
- Pentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats.
- Preclinical safety evaluation of body protective compound-157, a potential drug for treating various wounds.
- BPC 157 Rescued NSAID-cytotoxicity Via Stabilizing Intestinal Permeability and Enhancing Cytoprotection.
- Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion.
- Pentadecapeptide BPC 157 shortens duration of tetracaine- and oxybuprocaine-induced corneal anesthesia in rats.
- Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing
- Investigation of the effect for bisphenol A on oxidative stress in human hepatocytes and its interaction with catalase.
- Lipid peroxidation diminishing perspective of isolated theaflavins and thearubigins from black tea in arginine induced renal malfunctional rats.
- Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing.
- BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing.
- Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation
- Stress in Gastrointestinal Tract and Stable Gastric Pentadecapeptide BPC 157. Finally, do we have a Solution?
- Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
- Ginger extract modulates Pb-induced hepatic oxidative stress and expression of antioxidant gene transcripts in rat liver.
- In vivo effects of s-pantoprazole, polaprenzinc, and probiotic blend on chronic small intestinal injury induced by indomethacin.
- Empagliflozin lessened cardiac injury and reduced visceral adipocyte hypertrophy in prediabetic rats with metabolic syndrome.
- BPC 157: The counteraction of succinylcholine, hyperkalemia, and arrhythmias.
- Perforating corneal injury in rat and pentadecapeptide BPC 157.
- Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro.
- BPC 157 and blood vessels
- Protective effect of magnesium nitrate against neurological disorders provoked by cerebral ischemia in rats.
- Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts.
- Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157.
- Focus on ulcerative colitis: stable gastric pentadecapeptide BPC 157.
- The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration
- Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract
- Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat
- Lack of contribution of covalent benzo[a]pyrene-7,8-quinone-DNA adducts in benzo[a]pyrene-induced mouse lung tumorigenesis.
- Hair mercury levels of women of reproductive age in Ontario, Canada: implications to fetal safety and fish consumption.
- Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA): implications for cancer prevention.
- Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response.
- Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth
- Dietary Zn deficiency does not influence systemic blood pressure and vascular nitric oxide signaling in normotensive rats.
- Dose-response relationships for induction of CYP1A1 and CYP1A2 enzyme activity in liver, lung, and skin in female mice following subchronic exposure to polychlorinated biphenyls.
- Renal damage one year after first urinary tract infection: role of dimercaptosuccinic acid scintigraphy.
- Gadopentetate dimeglumine-enhanced chemical-shift MR imaging of the breast.
- Evaluation of Gd-DTPA-labeled dextran as an intravascular MR contrast agent: imaging characteristics in normal rat tissues.