BPC-157

3 shared conditions · 23 outcomes

TB-500 is a synthetic fragment of Thymosin Beta-4, a naturally occurring 43-amino acid peptide present in most human cells. It has been investigated for its potential role in tissue repair, wound healing, and regeneration. Research, primarily in animal models, suggests it may promote angiogenesis, cell migration, and reduce inflammation. Human clinical trials are limited.

3 shared conditions · 13 outcomes

GHRP-6 (Growth Hormone-Releasing Peptide-6) is a synthetic hexapeptide (His-DTrp-Ala-Trp-DPhe-Lys-NH2) that potently stimulates growth hormone secretion. Developed in the 1980s by Cyril Bowers, it was the first synthetic peptide shown to specifically elicit dose-dependent GH release both in vitro and in vivo. GHRP-6 acts through the ghrelin receptor (GHS-R1a) and CD36 receptor, exhibiting not only GH-releasing properties but also significant cytoprotective, cardioprotective, and wound healing effects. It increases IGF-1 levels, stimulates appetite, and has demonstrated tissue-protective properties in multiple preclinical and clinical studies. While primarily researched for GH deficiency, emerging evidence supports its potential in wound healing, scar prevention, and cardioprotection.

2 shared conditions · 15 outcomes

KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH) that exhibits potent anti-inflammatory and immunomodulatory properties. Preclinical studies have demonstrated significant efficacy in reducing intestinal inflammation in multiple models of inflammatory bowel disease, including DSS- and TNBS-induced colitis. Unlike full-length α-MSH, KPV's anti-inflammatory action is not primarily melanocortin receptor-mediated but is instead transported into cells via the PepT1 transporter. No human clinical trials have been conducted to date, limiting the evidence to animal and in vitro studies.

2 shared conditions · 23 outcomes

Humanin (HN) is a 24-amino-acid mitochondrial-derived peptide encoded within the 16S rRNA gene of mitochondrial DNA. Discovered in 2001 from preserved brain tissue of Alzheimer's patients, it demonstrates potent neuroprotective, cytoprotective, and metabolic regulatory effects. Humanin levels decline with age but remain stable in long-lived species and are elevated in offspring of centenarians.