KPV
PeptideKPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH) that exhibits potent anti-inflammatory and immunomodulatory properties. Preclinical studies have demonstrated significant efficacy in reducing intestinal inflammation in multiple models of inflammatory bowel disease, including DSS- and TNBS-induced colitis. Unlike full-length α-MSH, KPV's anti-inflammatory action is not primarily melanocortin receptor-mediated but is instead transported into cells via the PepT1 transporter. No human clinical trials have been conducted to date, limiting the evidence to animal and in vitro studies.
Quick Answer
What it is
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH) that exhibits potent anti-inflammatory and immunomodulatory properties. Preclinical studies have demonstrated significant efficacy in reducing intestinal inflammation in multiple models of inflammatory bowel disease, including DSS- and TNBS-induced colitis.
Key findings
- Grade C: GI Protection
- Grade C: Immune Function
- Grade C: Anti-Cancer Activity
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
⚠️ Research Notice
This peptide information is for educational and research purposes only. Peptides may not be FDA-approved for human use and may only be legally available for research purposes. Consult qualified healthcare professionals before considering any peptide compounds.
ℹ️ Quick Facts: KPV
Quick Facts: KPV
- Best Evidence:Grade C
- Conditions Studied:3
- Research Outcomes:15
- Key Effect:General Gut Health