Peptide
KPV
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH) that exhibits potent anti-inflammatory and immunomodulatory properties. Preclinical studies have demonstrated significant efficacy in reducing intestinal inflammation in multiple models of inflammatory bowel disease, including DSS- and TNBS-induced colitis. Unlike full-length α-MSH, KPV's anti-inflammatory action is not primarily melanocortin receptor-mediated but is instead transported into cells via the PepT1 transporter. No human clinical trials have been conducted to date, limiting the evidence to animal and in vitro studies.
- Updated
- How we grade
- 48 studies cited
Research notice. This page is for education and research. Peptides may not be FDA-approved for human use and may only be legally available for research. Talk to a qualified clinician before considering any peptide.
- Best evidence
- Grade C
- Conditions studied
- 3
- Outcomes
- 12
- Graded outcomes
- 0084
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
General
- GI Protection: improves
- Immune Function: improves
- Anti-Cancer Activity: improves
Skin Health
- Anti-inflammatory (Topical): improves
Key findings
- Pro-inflammatory Cytokine ReductionChanges; see studies
- Colitis Severity (Animal)Improves (the measure goes down)
- Intestinal Inflammation (Animal)Improves (the measure goes down)
Studies cited
48 studies from PubMed
- Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers.
- Exploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review.
- Challenges in clinical nutrition research in Latin America: A narrative review.
- A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment.
- PepT1-targeted nanodrug based on co-assembly of anti-inflammatory peptide and immunosuppressant for combined treatment of acute and chronic DSS-induced ColitiS.
- Non-contrast-enhanced magnetic resonance urography for measuring split kidney function in pediatric patients with hydronephrosis: comparison with renal scintigraphy.
- Learnings from the first AI-enabled skin cancer device for primary care authorized by FDA.
- Growth Factors-Loaded Temperature-Sensitive Hydrogel as Biomimetic Mucus Attenuated Murine Ulcerative Colitis via Repairing the Mucosal Barriers.
- The Melanocortin System in Inflammatory Bowel Diseases: Insights into Its Mechanisms and Therapeutic Potentials.
- Vimentin is required for tumor progression and metastasis in a mouse model of non-small cell lung cancer.
- Digital health technology in clinical trials.
- Interobserver Variability in CT-based Morphologic Tumor Response Assessment of Colorectal Liver Metastases.
- Skin-adaptive film dressing with smart-release of growth factors accelerated diabetic wound healing.
- A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon.
- Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia.
- Nocturnal Hypoventilation as a Respiratory Complication of Acute Flaccid Myelitis.
- In situ mucoadhesive hydrogel capturing tripeptide KPV: the anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositis.
- Biomimetic Melanosomes Promote Orientation-Selective Delivery and Melanocyte Pigmentation in the H(2)O(2)-Induced Vitiligo Mouse Model.
- Self-Cross-Linked Hydrogel of Cysteamine-Grafted γ-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in Rats.
- Subacute Neuropsychiatric Syndrome in Girls With SHANK3 Mutations Responds to Immunomodulation.
- A PepT1 mediated medicinal nano-system for targeted delivery of cyclosporine A to alleviate acute severe ulcerative colitis.
- Are melanocortin peptides future therapeutics for cutaneous wound healing?
- Mortality Risk Associated With Truncating Founder Mutations in Titin.
- Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis.
- Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin.
- Peptide Receptor-Targeted Fluorescent Probe: Visualization and Discrimination between Chronic and Acute Ulcerative Colitis.
- Structural and immunological feature of rhamnogalacturonan I-rich polysaccharide from Korean persimmon vinegar.
- Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.
- Percutaneous Coronary Intervention Using Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected Left Main Coronary Artery Stenosis: A Meta-Analysis of Randomized Trials.
- Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists.
- Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore.
- Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model.
- PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
- Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
- Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases.
- alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs.
- The antiinflammatory peptide alpha-melanocyte-stimulating hormone protects against the development of experimental colitis
- Immobilized alpha-melanocyte stimulating hormone 10-13 (GKPV) inhibits tumor necrosis factor-alpha stimulated NF-kappaB activity.
- Effects of the COOH-terminal tripeptide alpha-MSH(11-13) on corneal epithelial wound healing: role of nitric oxide.
- Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides
- New insights into the functions of alpha-MSH and related peptides in the immune system.
- The tripeptide Lys-Pro-Val inhibits LPS-induced synthesis of cytokines and expression of CD86 on macrophages
- Changes in glucocorticoid and mineralocorticoid receptors of liver and kidney cytosols after pathologic stress and its regulation in rats.
- Downregulation of glucocorticoid receptors of liver cytosols and the role of the inflammatory cytokines in pathological stress in scalded rats.
- [Changes in aldosterone binding activity of kidney cytosol after stress in rats and the regulation].
- The neuroimmunomodulatory peptide alpha-MSH.
- Antimicrobial effects of alpha-MSH peptides.
- Immunization against poliomyelitis: risk/benefit/cost in a changing context.