Condition
Chronic Nonspecific Knee Pain
Chronic nonspecific knee pain is characterized as long-term pain, stiffness, and decreased range of motion in the knee joint triggered by an unknown cause.
- Supplements studied
- 2
- Graded outcomes
- 1
- Trials
- 2
- People studied
- 102
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Osteoarthritis Symptoms Moderate Improvement | Improves (the measure goes down) | Moderate effect | 60 people | |||
| Pain | Improves (the measure goes down) | 1 study | 60 people | |||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Osteoarthritis Symptoms | Improves (the measure goes down) | 3 studies | 42 people | |||
Key findings
- Osteoarthritis SymptomsImproves (the measure goes down)
The Chronic Nonspecific Knee Pain Support protocol
2 primary supplements · 7 supporting supplements
- Collagen Peptides10–15 g hydrolyzed collagen daily
- Curcumin500–1,000 mg daily bioavailable formulation (with piperine or phytosome)
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Studies cited
57 studies from PubMed
- Effects of Withania somnifera supplementation on cognitive function: A systematic review and meta-analysis
- Effects of Ashwagandha (Withania somnifera) Supplementation on Exercise Performance: A Systematic Review and Meta-Analysis
- Ashwagandha (Withania somnifera) and its withanolides attenuate oxidative and inflammatory signaling in the nervous system
- Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis of randomized controlled trials
- Clinical effects of Ashwagandha (Withania somnifera) root extract on human health: A systematic review of reviews
- A Comprehensive Review on Pharmacological Activity of Withania somnifera (Ashwagandha)
- Effects of Ashwagandha (Withania somnifera) on Testosterone Levels: A Systematic Review and Meta-Analysis
- Ashwagandha (Withania somnifera)-Current Research on the Health-Promoting Activities: A Narrative Review
- Withania somnifera (L.) Dunal: A review of chemical composition and pharmacological activities
- Efficacy of Ashwagandha (Withania somnifera) in Improving Cardiorespiratory Endurance and Recovery in Healthy Athletic Adults: A Systematic Review
- Safety of Ashwagandha Root Extract: A Randomized, Placebo-Controlled, Study in Healthy Volunteers
- Examining the Neuroprotective Effects of Ashwagandha: Brain-Derived Neurotrophic Factor in Rats
- Evaluation of antioxidant potential of Rasayana drugs in healthy human volunteers
- An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda
- Effects of Withania somnifera in patients of schizophrenia: A randomized, double blind, placebo controlled pilot trial study
- Adjunctive Use of a Standardized Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study
- Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial
- Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers
- Effects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR Trial
- Effects of eight-week supplementation of Ashwagandha on cardiorespiratory endurance in elite Indian cyclists
- Effects of Ashwagandha ( Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis
- Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial
- Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials
- A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults
- Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study
- Efficacy of Withania somnifera on seminal plasma metabolites of infertile males: a proton NMR study at 800 MHz
- Withania somnifera Improves Semen Quality in Stress-Related Male Fertility
- Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males
- Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study
- Comparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility: A triple-blind randomised clinical trial
- A double-blind, placebo-controlled evaluation of the anxiolytic efficacy ff an ethanolic extract of withania somnifera
- Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974
- Safety and efficacy of Withania somnifera for anxiety and insomnia: Systematic review and meta-analysis.
- Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder
- Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions
- Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants
- A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males
- Efficacy of Ashwagandha (Withania somnifera Dunal. Linn.) in the management of psychogenic erectile dysfunction
- Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial
- An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study
- In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes
- Evaluation of the efficacy of Withania somnifera (Ashwagandha) root extract in patients with obsessive-compulsive disorder: A randomized double-blind placebo-controlled trial
- Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis
- Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study
- Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study
- A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain
- Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root
- Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults
- Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients
- The effect of hydro alcoholic nettle (Urtica dioica) extract on oxidative stress in patients with type 2 diabetes: a randomized double-blind clinical trial
- The effect of hydro alcoholic Nettle (Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes: a randomized double-blind control trial
- Stinging nettle cream for osteoarthritis
- Randomized controlled trial of nettle sting for treatment of base-of-thumb pain
- Cytokine secretion in whole blood of healthy subjects following oral administration of Urtica dioica L. plant extract
- Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study
- Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis
- Nettle sting for chronic knee pain: a randomised controlled pilot study