Collagen Peptides

Automated reading of the published studies (Decosa evidence engine), for outcomes Dr. Grey has not graded yet. It is not a Dr. Grey grade and does not change one. How it is read

• Hair growth

  The 2 studies read (114 people in all) mostly found an improvement in hair growth. The evidence is limited.

  2 studies counted of 7 read: 2 trials (114 people in the trials).

  1. Randomised trial, 2026; 114 people; women aged 20-50 with cellulite and hair thinning: improves. Hair diameter also increased significantly at week 24 Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic EvaluationPubMed 41788055
  2. Randomised trial, 2025; menopausal women: improves. significantly retarded hair shedding compared to the placebo Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled StudyPubMed 41002783

  Automated reading of the published studies (Decosa evidence engine), run 30 Sep 2026. It reads abstracts, can miss studies, and a repeat run can differ.

• Joint pain

  The best available review (2021, 15 studies) found an improvement in joint pain. That review studied recreational athletes, elderly, untrained pre-menopausal women. All 8 studies read agree. The evidence is moderate.

  8 studies counted of 9 read: 1 review and 7 trials (553 people in the trials).

  1. Systematic review, 2021; 15 studies; recreational athletes, elderly, untrained pre-menopausal women: improves (the review the verdict rests on). COL is most beneficial in improving joint functionality and reducing joint pain The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic reviewPubMed 34491424
  2. Randomised trial, 2025; 160 people; adult patients with osteoarthritis: improves. WOMAC scores were significantly lower in comparing HCP and placebo Evaluation of the Efficacy and Safety of CollaSel PRO® Type I and Type III Hydrolyzed Collagen Peptides in the Treatment of Osteoarthritis: A Double-Blind, Placebo-Controlled, Randomized Clinical TrialPubMed 40507417
  3. Randomised trial, 2025; 80 people; adults with knee osteoarthritis: improves. significantly reduced WOMAC pain compared to the placebo Efficacy and safety of low-molecular-weight collagen peptides in knee osteoarthritis: a randomized, double-blind, placebo-controlled trialPubMed 40977985
  4. Randomised trial, 2025; 31 people; patients with Grade 2-3 osteoarthritis: improves. notable enhancements across all osteoarthritis-related pain Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled studyPubMed 39719905
  5. Randomised trial, 2025; adults with grade II or III knee osteoarthritis: improves. significant reductions in VAS pain scores Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled studyPubMed 39839727
  6. Randomised trial, 2024; 182 people; healthy adults with functional knee and hip pain: improves. significantly reduced pain at rest (p = 0.018) Impact of Specific Bioactive Collagen Peptides on Joint Discomforts in the Lower Extremity during Daily Activities: A Randomized Controlled TrialPubMed 38928934
  7. Randomised trial, 2024; 100 people; adults with knee joint osteoarthritis: improves. Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and TolerabilityPubMed 38235711
  8. Randomised trial, 2023; middle-aged active adults: improves. pain only improved in high frequency exercisers Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adultsPubMed 37551682

  Automated reading of the published studies (Decosa evidence engine), run 30 Sep 2026. It reads abstracts, can miss studies, and a repeat run can differ.

• Knee pain

  The best available review (2023, 4 studies, 507 people) found a moderate improvement in knee pain. That review studied patients with knee osteoarthritis. 7 of the 8 studies read agree; 1 found no clear difference. The evidence is moderate.

  8 studies counted of 8 read: 1 review and 7 trials (697 people in the trials).

  1. Meta-analysis, 2023; 4 studies, 507 people; patients with knee osteoarthritis: improves (the review the verdict rests on). significant difference in pain relief between the collagen peptide group and the placebo group Analgesic efficacy of collagen peptide in knee osteoarthritis: a meta-analysis of randomized controlled trialsPubMed 37717022
  2. Randomised trial, 2025; 80 people; adults with knee osteoarthritis: improves. significantly reduced WOMAC pain compared to the placebo Efficacy and safety of low-molecular-weight collagen peptides in knee osteoarthritis: a randomized, double-blind, placebo-controlled trialPubMed 40977985
  3. Randomised trial, 2025; 31 people; patients with Grade 2-3 osteoarthritis: improves. yielded notable enhancements across all osteoarthritis-related pain Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled studyPubMed 39719905
  4. Randomised trial, 2025; adults with grade II or III knee osteoarthritis: improves. significant reductions in VAS pain scores Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled studyPubMed 39839727
  5. Randomised trial, 2024; 100 people; adults with knee joint osteoarthritis: improves. Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and TolerabilityPubMed 38235711
  6. Randomised trial, 2021; 180 people; young physically active adults with exercise-related knee pain: improves. significantly (p = 0.024) higher reduction of exercise-induced knee pain The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled TrialPubMed 33562729
  7. Randomised trial, 2020; 167 people; healthy physically active individuals with self-reported knee pain: no clear difference. similar decrease in VAS was observed after supplementation Effectiveness of collagen supplementation on pain scores in healthy individuals with self-reported knee pain: a randomized controlled trialPubMed 31990581
  8. Randomised trial, 2017; 139 people; athletes with functional knee problems: improves. statistically significant improvement in activity-related pain intensity Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptidesPubMed 28177710

  Automated reading of the published studies (Decosa evidence engine), run 30 Sep 2026. It reads abstracts, can miss studies, and a repeat run can differ.

• Muscle strength

  The best available review (2024, 19 studies, 768 people) found an improvement in muscle strength. That review studied healthy adults over 17 years. 5 of the 9 studies read agree; 4 found no clear difference. The evidence is limited.

  9 studies counted of 11 read: 2 reviews and 7 trials (350 people in the trials).

  1. Meta-analysis, 2024; 19 studies, 768 people; healthy adults over 17 years: improves (the review the verdict rests on). Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysisPubMed 39060741
  2. Systematic review, 2021; 15 studies; recreational athletes, elderly, untrained pre-menopausal women: improves. improvements in body composition, strength and muscle recovery The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic reviewPubMed 34491424
  3. Randomised trial, 2023; 39 people; young healthy males: no clear difference. did not differ between-groups (0.684 ≤ p ≤ 0.929) The effect of specific bioactive collagen peptides on function and muscle remodeling during human resistance trainingPubMed 36433662
  4. Randomised trial, 2022; 40 people; healthy male volunteers: no clear difference. muscle strength increased in both groups, with no statistical difference Effects of specific collagen peptide supplementation combined with resistance training on Achilles tendon propertiesPubMed 35403756
  5. Randomised trial, 2021; 97 people; middle-aged, untrained men: improves. leg strength (ΔCP-G = 163 ± 189 N; ΔP-G = 100 ± 154 N The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained Men: A Randomized Controlled TrialPubMed 33946565
  6. Randomised trial, 2021; 15 people; resistance-trained males: no clear difference. CP supplementation attenuated performance decline 24 hr Effects of Collagen Peptides on Recovery Following Eccentric Exercise in Resistance-Trained Males-A Pilot StudyPubMed 33186897
  7. Randomised trial, 2019; 77 people; premenopausal women: improves. significantly higher gain in hand-grip strength Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled TrialPubMed 31010031
  8. Randomised trial, 2019; 57 people; recreationally active young men: no clear difference. Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active MenPubMed 31126103
  9. Randomised trial, 2019; 25 people; young recreationally active men: improves. slightly higher increase in COL compared with PLA Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Skeletal Muscle Proteome in Recreationally Active MenPubMed 31091754

  Automated reading of the published studies (Decosa evidence engine), run 30 Sep 2026. It reads abstracts, can miss studies, and a repeat run can differ.

• Skin aging

  The best available review (2026, 19 studies, 1,341 people) found an improvement in skin aging. 5 of the 7 studies read agree; 2 found mixed results. The evidence is moderate.

  7 studies counted of 11 read: 2 reviews and 5 trials (343 people in the trials).

  1. Systematic review, 2026; 19 studies, 1,341 people: improves (the review the verdict rests on). modest pooled effect on wrinkle reduction (MD = 0.27, p = 0.04) Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trialsPubMed 41924746
  2. Systematic review, 2020; 10 studies: improves. improves clinical manifestation of skin health Collagen supplementation for skin health: A mechanistic systematic reviewPubMed 32436266
  3. Randomised trial, 2024; 112 people; healthy adult females: mixed results. significant improvements in skin elasticity (p = 0.009) The Efficacy and Safety of CollaSel Pro® Hydrolyzed Collagen Peptide Supplementation without Addons in Improving Skin Health in Adult Females: A Double Blind, Randomized, Placebo-Controlled Clinical Study Using Biophysical and Skin Imaging TechniquesPubMed 39336856
  4. Randomised trial, 2024; 85 people; healthy East Asian women aged 43 to 65: improves. significant improvement of dermis density and skin moisture Influence of collagen peptide supplementation on visible signs of skin and nail health and -aging in an East Asian population: A double blind, randomized, placebo-controlled trialPubMed 39143887
  5. Randomised trial, 2022; 100 people: improves. 10-grade crow's feet photo scale score, eye wrinkle volume, skin roughness parameters Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled StudyPubMed 36516059
  6. Randomised trial, 2021; 46 people; healthy females aged 45 to 59 years: improves. significant reduction in wrinkles and an increase of dermis echogenicity Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical StudyPubMed 34443468
  7. Randomised trial, 2015: mixed results. significantly increased skin hydration after 8 weeks The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trialsPubMed 26362110

  Automated reading of the published studies (Decosa evidence engine), run 30 Sep 2026. It reads abstracts, can miss studies, and a repeat run can differ.