MSM
MSM is an organosulfur compound naturally found in foods, often marketed for joint health. C-grade evidence for osteoarthritis symptoms (small effect). Also studied for allergies and exercise recovery. Provides sulfur which is important for connective tissue. Often combined with glucosamine/chondroitin. Related to DMSO but is NOT the same compound. Generally well-tolerated with good safety profile. Evidence is weaker than glucosamine/chondroitin.
Quick Answer
What it is
MSM is an organosulfur compound naturally found in foods, often marketed for joint health. C-grade evidence for osteoarthritis symptoms (small effect).
Key findings
- Grade C: Osteoarthritis Symptoms (Osteoarthritis (OA))
- Grade C: Exercise-Induced Oxidation (Muscle Recovery)
- Grade C: Allergy Symptoms (Allergic Rhinitis (Seasonal Allergies / Hay Fever))
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
βΉοΈ Quick Facts: MSM
Quick Facts: MSM
- Best Evidence:Grade C
- Conditions Studied:6
- Research Outcomes:15
- Key Effect:Muscle Recovery
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (7)
Related Supplements
Vitamin D
4 shared conditions Β· 308 outcomes
Vitamin D is a fat-soluble vitamin that our skin synthesizes when exposed to the sun. It benefits us in many ways, from bone health to mood.
Spirulina
4 shared conditions Β· 304 outcomes
Spirulina, commonly known as βblue-green algaeβ, is a nontoxic cyanobacterium that is rich in various nutrients and bioactive pigments and polyphenols. Spirulina contains many antioxidant compounds and could have beneficial cardiometabolic effects.
Creatine
4 shared conditions Β· 433 outcomes
Creatine is among the most well-studied and effective supplements for improving exercise performance. It does this mainly by increasing energy availability during high-intensity activity. Creatine may also provide cognitive and mental health benefits in some contexts.
L-Carnitine
4 shared conditions Β· 558 outcomes
L-carnitine can relieve leg pain in people with peripheral artery disease (PAD) and treat some aspects of metabolic syndrome. Although itβs often also used for fat loss, its effectiveness for that is questionable.
Ashwagandha
4 shared conditions Β· 318 outcomes
Ashwagandha has been called the king of Ayurvedic herbs. Itβs best known for reducing stress and anxiety. It may also modestly enhance various aspects of physical performance, increase testosterone levels, and improve reproductive health, but more research is needed to confirm these effects.
Vitamin C
3 shared conditions Β· 262 outcomes
Vitamin C, or ascorbic acid, is an essential vitamin and a very popular supplement due to its antioxidant properties, safety profile, and low price. Many people supplement with vitamin C because it is believed to reduce symptoms of the common cold.
Stinging Nettle
3 shared conditions Β· 16 outcomes
Stinging nettle (Urtica dioica) is a perennial plant that can cause painful reactions when it comes in contact with the skin. It has been used for many years as a medicinal vegetable in the treatment of pain, bleeding, urinary tract diseases, and allergies.
Sodium Bicarbonate
3 shared conditions Β· 132 outcomes
Sodium bicarbonate (baking soda) is an evidence-based ergogenic aid for high-intensity exercise. B-grade evidence for running and aerobic performance via acid buffering. Works by increasing blood buffering capacity, allowing muscles to tolerate more lactic acid. Best for high-intensity efforts lasting 1-7 minutes. MAJOR DRAWBACK: GI distress is common (nausea, cramping, diarrhea) - known as 'bicarb shits' by athletes. Serial loading protocols may reduce GI issues. Also used medically for CKD acidosis.