Molybdenum
Molybdenum is an essential trace mineral required as a cofactor for four critical enzymes: sulfite oxidase (sulfur amino acid metabolism), xanthine oxidase (purine catabolism to uric acid), aldehyde oxidase (drug and xenobiotic metabolism), and mitochondrial amidoxime reducing component (mARC, detoxification). The molybdenum cofactor (Moco) is synthesized endogenously and incorporated into these enzymes. Molybdenum is readily obtained from legumes, grains, nuts, and leafy vegetables. The RDA is 45mcg/day for adults. Deficiency is extremely rare except in cases of genetic molybdenum cofactor deficiency (a severe inherited disorder) or prolonged total parenteral nutrition without molybdenum. Supplementation may benefit individuals with sulfite sensitivity or those on TPN. The Tolerable Upper Intake Level (UL) is 2mg/day; excess intake can interfere with copper metabolism.
Quick Answer
What it is
Molybdenum is an essential trace mineral required as a cofactor for four critical enzymes: sulfite oxidase (sulfur amino acid metabolism), xanthine oxidase (purine catabolism to uric acid), aldehyde oxidase (drug and xenobiotic metabolism), and mitochondrial amidoxime reducing component (mARC, detoxification). The molybdenum cofactor (Moco) is synthesized endogenously and incorporated into these enzymes.
Key findings
- Grade A: Serum Molybdenum Levels (Molybdenum Deficiency)
- Grade A: Sulfite Levels (Molybdenum Deficiency)
- Grade B: Sulfite Oxidase Activity (Sulfite Sensitivity)
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
âšī¸ Quick Facts: Molybdenum
Quick Facts: Molybdenum
- Best Evidence:Grade A
- Conditions Studied:8
- Research Outcomes:13
- Grade A Findings:2
- Grade B Findings:4
- Key Effect:Molybdenum Deficiency
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (10)
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