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Cissus Quadrangularis

Cissus quadrangularis is a climbing plant related to grapevines, and its stems have long been used in traditional medicine for bone and joint complaints. Research is thin: in a small group of people with obesity, oxidative stress markers went down while creatinine, a marker of kidney function, went up, and in a tiny osteoarthritis study blood pressure showed no clear difference. The evidence is limited to very limited, so these results are early.

Sources: PMID 24113700

Best evidence
Grade C
Conditions studied
4
Outcomes
10
Graded outcomes
0021

Evidence by condition

  • Strong
  • Moderate
  • Limited
  • Very limited

4 conditions

Obesity

Obesity: outcomes studied for Cissus Quadrangularis
GradeOutcomeEffectSizeStudiesPeopleStudies list
Creatinine

Small Increase

Improves (the measure goes up)Small effect153 people
Oxidative Stress Biomarkers

Small Decrease

Improves (the measure goes down)Small effect153 people
WeightImproves (the measure goes down)1 study153 people

Studies that measured weight

Total cholesterolImproves (the measure goes down)153 people
TriglyceridesImproves (the measure goes down)153 people

Osteoarthritis (OA)

Osteoarthritis (OA): outcomes studied for Cissus Quadrangularis
GradeOutcomeEffectSizeStudiesPeopleStudies list
Blood Pressure

No effect

NoneNo effect1 study29 people

Studies that measured blood pressure

Functionality in Elderly or InjuredImproves (the measure goes up)29 people
PainImproves (the measure goes down)29 people

Bone Health

  • Fracture Healing: improves
Bone Health: outcomes studied for Cissus Quadrangularis
GradeOutcomeEffectSizeStudiesPeopleStudies list
Fracture HealingImproves (the measure goes up)1 study11 people

Studies that measured fracture healing

Hemorrhoids

  • Hemorrhoids Symptoms: improves
Hemorrhoids: outcomes studied for Cissus Quadrangularis
GradeOutcomeEffectSizeStudiesPeopleStudies list
Hemorrhoids SymptomsImproves (the measure goes down)1 study570 people

Studies that measured hemorrhoids symptoms

Key findings

  • CreatinineObesityImproves (the measure goes up)
  • Oxidative Stress BiomarkersObesityImproves (the measure goes down)
  • Blood PressureOsteoarthritis (OA)

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Third-party tested Cissus Quadrangularis products. The evidence above is limited, so read it before you buy.

  • Grade C

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Studies cited

4 studies from PubMed

  1. The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stressLipids Health Dis · PMID 17274828
  2. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoidsJ Med Assoc Thai · PMID 21344797
  3. Cissus quadrangularis reduces joint pain in exercise-trained men: a pilot studyPhys Sportsmed · PMID 24113700
  4. Clinical evaluation of cissus quadrangularis and moringa oleifera and osteoseal as osteogenic agents in mandibular fractureNatl J Maxillofac Surg · PMID 22639499