Protocol · Dermatological Health
Psoriasis Supportive Care Protocol
Omega-3 Fatty Acids and Vitamin D are the core of this stack, with 7 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Psoriasis Supportive Care.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
9 supplements · 1 graded
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Omega-3 Fatty Acids | Amount listed: 3–4 g EPA+DHA daily | Anti-inflammatory; may reduce psoriasis severity; competes with pro-inflammatory omega-6s | Not graded yet | ||
| Vitamin D | Amount listed: 2,000–4,000 IU daily (higher doses under medical supervision) | Immune modulation; topical vitamin D analogs are standard treatment; oral supplementation may help | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Curcumin | Amount listed: 500–2,000 mg daily with enhanced absorption form | Anti-inflammatory; modulates TNF-alpha and other cytokines involved in psoriasis | Not graded yet | ||
| Probiotics | Amount listed: 20–50 billion CFU daily (multi-strain) | Gut-skin axis; modulates immune response; may reduce systemic inflammation
| Grade B for C-Reactive Protein (CRP)2 studies · 400 people | ||
| Milk Thistle (Silymarin) | Amount listed: 200–400 mg silymarin daily | Antioxidant; liver support; may help with psoriasis through anti-inflammatory effects | Not graded yet | ||
| Vitamin B12 (Topical) | Amount listed: Topical cream applied to plaques twice daily | Topical B12 cream has been studied for psoriasis with some positive results | Not graded yet | ||
| Selenium | Amount listed: 100–200 mcg daily | Antioxidant; may be low in psoriasis patients; supports immune function | Not graded yet | ||
| Zinc | Amount listed: 15–30 mg daily | Supports skin healing; may be low in psoriasis; immune modulation
| Not graded yet | ||
| Oregon Grape (Mahonia aquifolium) | Amount listed: Topical cream applied to plaques twice daily | Topical extract has shown benefit for psoriasis; anti-inflammatory and antiproliferative | Not graded yet | ||
Shop the evidence-backed picks
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
The supplement in this protocol graded A or B. Each opens third-party tested products, matched to the dose above where we can.
- Grade B
We earn from purchases made in our Fullscript store, and links to Fullscript, iHerb or Thorne carry our referral, so we may earn a commission at no extra cost to you. Grades come from the research and never change based on what we earn. Full disclosure
How this protocol works
In plain language
Psoriasis is a chronic autoimmune condition that causes rapid skin cell buildup, resulting in scaling, redness, and inflammation. It affects about 2-3% of the population and can significantly impact quality of life. Psoriasis is not just a skin disease - it's associated with systemic inflammation and increased risk of cardiovascular disease, metabolic syndrome, and psoriatic arthritis.
TYPES OF PSORIASIS:
- Plaque psoriasis (80%): Red patches with silvery scales
- Guttate: Small, drop-shaped spots
- Inverse: Smooth, red patches in skin folds
- Pustular: White pustules surrounded by red skin
- Erythrodermic: Widespread redness (medical emergency)
CRITICAL: Psoriasis requires medical treatment. This protocol is SUPPORTIVE alongside standard therapy.
MEDICAL TREATMENTS:
- Topical: Corticosteroids, vitamin D analogs (calcipotriene), retinoids, coal tar
- Phototherapy: UVB, PUVA
- Systemic: Methotrexate, cyclosporine, acitretin
- Biologics: TNF inhibitors, IL-17/IL-23 inhibitors (highly effective)
LIFESTYLE FACTORS:
- Stress management (triggers flares)
- Weight management (obesity worsens psoriasis)
- Alcohol moderation
- Smoking cessation
- Moisturizing regularly
Omega-3 Fatty Acids* reduce inflammation and may help reduce psoriasis severity.
Vitamin D* is important since topical vitamin D is a standard treatment.
Probiotics* may help through the gut-skin axis connection.
Topical treatments* like Oregon Grape extract and vitamin B12 cream have some evidence.
Expected timeline: Psoriasis is chronic. Supplements may provide modest improvement over 2-3 months. Best results with comprehensive approach including medical treatment and lifestyle changes.