Protocol · Metabolic & Endocrine
Obesity & Weight Management Protocol
Glucomannan and Protein (Whey/Casein) are the core of this stack, with 4 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Obesity & Weight Management.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
6 supplements · 4 graded · 7 confirmed studies
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Glucomannan | Amount listed: 1 g 30 min before meals with water (3 g/day total) | Soluble fiber expands in stomach to increase satiety, delays gastric emptying, and reduces calorie absorption | Not graded yet | ||
Confirmed studies for Glucomannan (titles as PubMed lists them) | |||||
| Protein (Whey/Casein) | Amount listed: 25–50 g daily (1.2–1.6 g/kg body weight total protein) | Increases satiety hormones (GLP-1, PYY), preserves lean muscle mass during weight loss, and has high thermic effect
| Grade B for Blood glucose1 study · 2,344 people | ||
Confirmed studies for Protein (Whey/Casein) (titles as PubMed lists them) | |||||
| Supporting stackListed as additions to the core | |||||
| Green Tea Extract (EGCG) | Amount listed: 250–500 mg EGCG daily (or 3–4 cups green tea) | Catechins increase fat oxidation and thermogenesis by inhibiting COMT and prolonging norepinephrine action
| Grade C for Blood Pressure6 studies · 88 people | ||
Confirmed studies for Green Tea Extract (EGCG) (titles as PubMed lists them) | |||||
| Caffeine | Amount listed: 100–400 mg daily (adjust based on tolerance) | Stimulates thermogenesis via sympathetic nervous system activation and enhances fat oxidation | Not graded yet | ||
Confirmed studies for Caffeine (titles as PubMed lists them) | |||||
| Saffron Extract | Amount listed: 88.25–176.5 mg standardized extract daily | Reduces snacking and emotional eating by modulating serotonin pathways and reducing compulsive food cravings
| Grade B for Blood glucose6 studies · 624 people | ||
Confirmed studies for Saffron Extract (titles as PubMed lists them) | |||||
| Conjugated Linoleic Acid (CLA) | Amount listed: 3–6 g daily | Modulates adipocyte metabolism, promotes lipolysis, and may reduce body fat accumulation
| Grade D for Adiponectin142 people | ||
Confirmed studies for Conjugated Linoleic Acid (CLA) (titles as PubMed lists them) | |||||
Shop the evidence-backed picks
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
The 2 supplements in this protocol graded A or B. Each opens third-party tested products, matched to the dose above where we can.
- Grade B
- Grade B
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How this protocol works
In plain language
Obesity is a complex metabolic condition involving energy imbalance, hormonal dysregulation, and often behavioral factors like emotional eating. While diet and exercise remain foundational, certain supplements can support weight loss by increasing satiety, boosting metabolism, or reducing cravings. These should complement—not replace—lifestyle changes.
- Glucomannan is a highly effective natural fiber derived from konjac root. When taken with water before meals, it expands dramatically in the stomach (up to 50x its weight), creating a feeling of fullness that reduces food intake. Studies show consistent weight loss of 3-4 lbs over 8 weeks with no diet changes. It also slows carbohydrate absorption and feeds beneficial gut bacteria.
- Protein Supplementation (whey or casein) supports weight loss in multiple ways: it increases satiety hormones, has the highest thermic effect of any macronutrient (25-30% of calories burned during digestion), and critically helps preserve muscle mass during calorie restriction. Losing muscle slows metabolism—protein prevents this.
- Green Tea Extract (EGCG) boosts fat burning by inhibiting an enzyme that breaks down norepinephrine, prolonging its fat-mobilizing effects. The combination of EGCG and caffeine is synergistic, increasing 24-hour energy expenditure by 4-5%. Effects are modest but meaningful over time.
- Caffeine increases metabolic rate and fat oxidation through stimulation of the sympathetic nervous system. It also improves exercise performance, allowing for more intense workouts. Tolerance develops, so cycling (5 days on, 2 off) helps maintain effects.
- Saffron Extract is particularly useful for emotional or compulsive eating. It works on serotonin pathways to reduce cravings and snacking behavior. Studies in women showed significant reductions in snacking frequency.
- CLA (Conjugated Linoleic Acid) may help reduce body fat accumulation over time, though effects are modest (about 0.1kg fat loss per week). It works best as part of a comprehensive weight loss program.
Expected timeline: Glucomannan's satiety effects are immediate. Metabolic effects from green tea/caffeine begin within days. Measurable weight loss typically requires 4-8 weeks of consistent use alongside calorie reduction.