Protocol · Kidney & Urinary Health
Kidney Health & Function Support Protocol
Omega-3 Fatty Acids and Resveratrol are the core of this stack, with 7 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Kidney Health & Function Support.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
9 supplements · 1 graded
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Omega-3 Fatty Acids | Amount listed: 2–4 g EPA+DHA daily | May reduce inflammation and proteinuria; supports cardiovascular health in CKD patients | Not graded yet | ||
| Resveratrol | Amount listed: 100–500 mg daily | Antioxidant and anti-inflammatory that may protect kidney function and reduce oxidative stress
| Grade B for Blood Urea Nitrogen (BUN)894 people | ||
| Supporting stackListed as additions to the core | |||||
| Vitamin D | Amount listed: 1,000–2,000 IU daily (active vitamin D if advanced CKD) | Deficiency very common in CKD; supplementation important but requires monitoring | Not graded yet | ||
| Coenzyme Q10 | Amount listed: 100–200 mg daily | Antioxidant that may reduce oxidative stress and support mitochondrial function in kidney cells | Not graded yet | ||
| Probiotics | Amount listed: 10–20 billion CFU daily | May reduce uremic toxins by modulating gut microbiome in CKD patients | Not graded yet | ||
| Sodium Bicarbonate | Amount listed: As prescribed based on bicarbonate levels (typically 650–1,300 mg 2–3 times daily) | Corrects metabolic acidosis in CKD; may slow disease progression | Not graded yet | ||
| Alpha-Lipoic Acid | Amount listed: 300–600 mg daily | Antioxidant that may protect kidneys from oxidative damage, especially in diabetic nephropathy | Not graded yet | ||
| NAC (N-Acetylcysteine) | Amount listed: 600–1,200 mg daily | Glutathione precursor that may protect against contrast-induced nephropathy and oxidative stress
| Not graded yet | ||
| B Vitamins | Amount listed: Kidney-friendly B-complex as directed | Addresses elevated homocysteine common in CKD; supports overall metabolism | Not graded yet | ||
Shop the evidence-backed picks
The supplement in this protocol graded A or B. Each opens third-party tested products, matched to the dose above where we can.
- Grade B
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How this protocol works
In plain language
Kidney health is crucial as the kidneys filter waste, balance fluids, regulate blood pressure, produce hormones, and maintain mineral balance. Chronic kidney disease (CKD) affects about 15% of adults and can progress silently to kidney failure. Risk factors include diabetes, high blood pressure, heart disease, and family history. While preventing progression requires managing underlying conditions, certain supplements may support kidney function and address complications.
CRITICAL: CKD requires nephrology care. Many supplements need dose adjustment or are contraindicated in kidney disease. Avoid high-dose vitamin A, potassium supplements, and excessive protein without guidance. Some herbal supplements can be nephrotoxic. ALWAYS discuss supplements with your nephrologist before taking them.
Omega-3 Fatty Acids* may help reduce inflammation and proteinuria (protein in urine) in kidney disease. They also support cardiovascular health, which is especially important since heart disease is the leading cause of death in CKD patients.
Resveratrol* has antioxidant and anti-inflammatory properties that may protect kidney cells from damage. Research suggests it may help preserve kidney function, particularly in the context of diabetes-related kidney disease.
Vitamin D* deficiency is extremely common in CKD because the kidneys normally activate vitamin D. Low vitamin D contributes to bone disease, muscle weakness, and cardiovascular risk. Supplementation is often necessary but requires monitoring, and advanced CKD may require active vitamin D (calcitriol or analogs).
CoQ10* supports mitochondrial energy production and has antioxidant effects. It may help reduce oxidative stress that contributes to kidney damage.
Probiotics* are increasingly recognized as beneficial in CKD. The gut microbiome is altered in kidney disease, producing uremic toxins. Probiotics may reduce these toxins and improve symptoms.
Sodium Bicarbonate* helps correct metabolic acidosis, a common complication of CKD that can accelerate disease progression and worsen bone and muscle health.
Alpha-Lipoic Acid* may help protect against diabetic nephropathy through its antioxidant effects.
NAC* provides cysteine to make glutathione, the body's major antioxidant. It may help protect kidneys from contrast dye damage and oxidative stress.
B Vitamins* help address elevated homocysteine levels common in CKD and support overall metabolism. CKD patients often need supplementation, but water-soluble vitamins are lost during dialysis.
Expected timeline: These supplements provide ongoing support. Effects on kidney function parameters may take months to assess. Vitamin D: check levels in 8-12 weeks. Acidosis correction: monitor bicarbonate levels. Work closely with your nephrologist for monitoring.