Protocol · Cardiovascular Health
Inflammatory Venous Disease Support Protocol
Horse Chestnut Seed Extract (Aescin) and Diosmin-Hesperidin (Micronized Purified Flavonoid Fraction) are the core of this stack, with 6 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Inflammatory Venous Disease Support.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
8 supplements · 1 graded
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Horse Chestnut Seed Extract (Aescin) | Amount listed: 300 mg standardized extract (50 mg aescin) twice daily | Strengthens vein walls, reduces inflammation and capillary permeability; well-studied for venous insufficiency | Not graded yet | ||
| Diosmin-Hesperidin (Micronized Purified Flavonoid Fraction) | Amount listed: 500 mg twice daily or 1,000 mg once daily | Venoactive flavonoids that improve venous tone, reduce inflammation, and decrease capillary leakage | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Pycnogenol (Pine Bark Extract) | Amount listed: 100–200 mg daily | Antioxidant and anti-inflammatory; strengthens capillaries and improves venous symptoms | Not graded yet | ||
| Butcher's Broom (Ruscus aculeatus) | Amount listed: 150 mg extract twice daily | Contains ruscogenins that improve vein tone and reduce inflammation | Not graded yet | ||
| Grape Seed Extract | Amount listed: 150–300 mg daily | Oligomeric proanthocyanidins strengthen blood vessel walls and reduce inflammation | Not graded yet | ||
| Serrapeptase | Amount listed: 60,000–120,000 SPU daily on empty stomach | Proteolytic enzyme with anti-inflammatory effects; may reduce swelling in venous disease
| Grade C for Pain1 study · 40 people | ||
| Vitamin C | Amount listed: 500–1,000 mg daily | Essential for collagen synthesis; supports blood vessel integrity | Not graded yet | ||
| Omega-3 Fatty Acids | Amount listed: 2–3 g EPA+DHA daily | Anti-inflammatory effects may help reduce venous inflammation | Not graded yet | ||
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Inflammatory Venous Disease. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
- Grade C
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How this protocol works
In plain language
Inflammatory venous disease encompasses conditions where vein walls become inflamed and weakened, including chronic venous insufficiency (CVI), varicose veins, and post-thrombotic syndrome. In CVI, damaged valves in leg veins allow blood to pool, causing swelling, pain, skin changes, and potentially ulcers. Inflammation plays a key role in progression. While compression stockings and exercise are foundational, several supplements have good evidence for supporting vein health.
CRITICAL: If you have sudden leg swelling, pain, or redness, see a doctor urgently to rule out deep vein thrombosis (DVT), which is a medical emergency. Venous ulcers require medical care. These supplements support vein health but don't replace compression therapy, exercise, or medical treatment for advanced disease.
Horse Chestnut Seed Extract (Aescin)* has the strongest evidence for venous disease. Cochrane reviews confirm it reduces leg swelling, pain, and heaviness in chronic venous insufficiency. It works by strengthening vein walls and reducing capillary leakage.
Diosmin-Hesperidin* is a combination of venoactive flavonoids from citrus. It improves vein tone, reduces inflammation, and decreases capillary permeability. It is widely prescribed in Europe for venous disorders.
Pycnogenol* (Pine Bark Extract) contains proanthocyanidins that strengthen blood vessels, reduce inflammation, and improve venous symptoms.
Butcher's Broom* contains ruscogenins that have venotonic and anti-inflammatory effects. It may help reduce leg swelling and heaviness.
Grape Seed Extract* provides oligomeric proanthocyanidins that support blood vessel integrity and reduce inflammation.
Serrapeptase* is a proteolytic enzyme with anti-inflammatory effects that may help reduce swelling.
Vitamin C* is essential for collagen synthesis, which is important for vein wall structure.
Omega-3 Fatty Acids* provide anti-inflammatory effects that may help reduce venous inflammation.
Expected timeline: Horse chestnut and venoactive flavonoids: improvement in symptoms within 2-4 weeks with continued benefit over months. Compression stockings work immediately. Exercise and leg elevation help daily. These supplements work best alongside lifestyle measures.