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Epitalon

Peptide

Epitalon (Epithalamin) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) that activates telomerase, the enzyme responsible for maintaining telomere length. Developed from over 35 years of Russian research on pineal gland extracts, it may support cellular longevity and regulate melatonin production. Note: Epitalon is a research peptide not approved by the FDA for human use and is not available as a regulated pharmaceutical in most countries.

Quick Answer

What it is

Epitalon (Epithalamin) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) that activates telomerase, the enzyme responsible for maintaining telomere length. Developed from over 35 years of Russian research on pineal gland extracts, it may support cellular longevity and regulate melatonin production.

Key findings

  • Grade C: Oxidative Stress
  • Grade C: Sleep Quality
  • Grade C: Telomerase Activity (Aging & Longevity)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

⚠️ Research Notice

This peptide information is for educational and research purposes only. Peptides may not be FDA-approved for human use and may only be legally available for research purposes. Consult qualified healthcare professionals before considering any peptide compounds.

ℹ️ Quick Facts: Epitalon

Quick Facts: Epitalon

  • Best Evidence:Grade C
  • Conditions Studied:4
  • Research Outcomes:20
  • Key Effect:Aging & Longevity
A0
B0
C11
D9
4 conditions · 20 outcomes

Detailed Outcomes

|
C
Oxidative Stress
7 preclinical studies support this finding. Primarily preclinical evidence.
small↓Improves
C
Sleep Quality
5 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
C
Lipid Profile
3 preclinical studies support this finding. Primarily preclinical evidence.
small↓Improves
C
Reproductive Outcomes
3 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
D
Cognitive Function
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
D
Muscle Mass/Function
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
D
Anti-Inflammatory Activity
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
D
Cancer Cell Apoptosis
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
D
GI Protection
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
D
Kidney Function
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
C
Telomerase Activity
Moderate increase in telomerase activation
moderate↑Improves
C
Telomere Length
Small increase in telomere length observed
small↑Improves
C
Melatonin Production
Moderate increase in nocturnal melatonin
moderate↑Improves
D
Sleep Architecture
Small improvement in sleep quality
small↑Improves
C
Pineal Gland Function
Small improvement in pineal function markers
small↑Improves
D
T-Cell Activity
Small increase in T-cell function
2 studies
small↑Improves
D
Thymus Function
Preliminary thymus support observed
1 study
small↑Improves

Research Citations (57)

Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
(2025)
PMID: 40141333
The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
(2025)
PMID: 40493162
Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.
(2022)
PMID: 35408963
Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro.
(2022)
PMID: 35413689
[Main mechanisms of rhabdomyolysis-caused kidney injury and their correction by organospecific peptides].
(2014)
PMID: 25730989
[Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data].
(2014)
PMID: 25826983
Effects of melatonin and epithalamin on the content of protein and lipid peroxidation products in rat cortex and hippocampus under conditions of acute hypoxia.
(2012)
PMID: 23330089
[Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging].
(2012)
PMID: 23289226
Melatonin and pineal gland peptides are able to correct the impairment of reproductive cycles in rats.
(2012)
PMID: 23237594
Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people
(2007)
PMID: 17969590

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