Condition
Endocrine Function
Endocrine function describes how the body's hormone-producing glands, such as the thyroid, adrenals, pancreas and pineal gland, release chemical messengers that steer metabolism, growth, sleep and stress responses. Among supplements, the peptide epitalon has been looked at for pineal gland function, and studies found a small improvement in markers of how that gland worked. The evidence is limited, though: it rests on five small studies with 65 people in total, so it's too early to say how much this matters in daily life.
Sources: PMID 15452611; PMID 40141333
- Updated
- How we grade
- 57 studies cited
- Supplements studied
- 0
- Medicines and peptides
- 1
- Graded outcomes
- 1
No supplement studies yetWe haven’t found supplement studies for Endocrine Function. The medicines and peptides studied for it are listed below.
Prescription medicines and peptides studied, for context
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Pineal Gland Function Small improvement in pineal function markers | Improves (the measure goes up) | Small effect | 5 studies | 65 people | ||
Studies that measured pineal gland function
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Key findings
- Pineal Gland FunctionImproves (the measure goes up)
Studies cited
57 studies from PubMed
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
- The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
- Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.
- Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro.
- [Main mechanisms of rhabdomyolysis-caused kidney injury and their correction by organospecific peptides].
- [Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data].
- Effects of melatonin and epithalamin on the content of protein and lipid peroxidation products in rat cortex and hippocampus under conditions of acute hypoxia.
- [Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging].
- Melatonin and pineal gland peptides are able to correct the impairment of reproductive cycles in rats.
- Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people
- [Age-related changes of exercise capacity and some biochemical indices of rat muscles under influence of different light conditions and pineal preparations].
- Antioxidant properties of geroprotective peptides of the pineal gland.
- Effect of epithalamin on the rhythm of immune and endocrine systems functioning in patients with chronic coronary disease.
- Anti-aging peptide bioregulators induce reactivation of chromatin.
- [Comparative study of the effects of melatonin and epitalon on the protracted memory under the shuttle labyrinth test conditions in rats in the course of aging].
- [Influence of light regimens, melatonin, and epitalon on amylase activity in the pancreas and small intestine in rats of different age].
- [Effect of age, different light conditions, melatonin, and epitalon on lysosomal proteinase activity in the liver and kidneys of rats].
- Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas
- [Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)].
- Antigen-induced changes in the endocrine function of the thymus in CBA mice during aging: role of peptide factors released by the pineal gland.
- Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people
- Effects of pineal peptides on circadian dynamics of spermatogonia proliferation in albino rats.
- Effect of epithalamin on circadian relationship between the endocrine function of the thymus and melatonin-producing function of the pineal gland in elderly people.
- [The pineal gland's peptides factors and the rhythms of functions of the thymus and bone marrow in animals during aging].
- [Effect of epitalon on the immunity and hemostasis in hypophysectomized chicken and old hens].
- Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
- The role of pineal gland in breast cancer development.
- [Effect of epithalamin on free-radical reactions in the formed elements of blood from breast cancer patients].
- Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.
- [Regulating effect of pineal gland peptides on development of T-lymphocytes in CBA aging mice: role of microenvironment of immune system organs and neuroendocrine factors].
- Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa.
- Peptides and Ageing
- Aging of the pineal gland
- Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.
- Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice.
- Effects of epithalon on activities gastrointestinal enzymes in young and old rats.
- Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys.
- Effect of pineal tetrapeptide on antioxidant defense in Drosophila melanogaster.
- Studies of cytokines in nerve tissue cultures.
- Peptide bioregulators inhibit apoptosis.
- [Long-term results of comprehensive treatment for cervical cancer with poor prognosis].
- [Effect of melatonin and epithalamin on the antioxidant defense system activity in rats].
- Effect of melatonin and pineal peptide preparation epithalamin on life span and free radical oxidation in Drosophila melanogaster.
- [Comparison of the antioxidant properties of melatonin, epithalamin, and glutathione by the method of luminol-dependent chemiluminescence in vitro].
- [Effect of melatonin and epithalamin on life span and lipid peroxidation in Drosophila melanogaster].
- [Melatonin and epithalamin extinguishes the lipid peroxidation process in rats].
- [Melatonin and epithalamin inhibit the process of free radical oxidation in rats].
- Twenty years of study on effects of pineal peptide preparation: epithalamin in experimental gerontology and oncology.
- [The use of peptide preparations of the epiphysis (pineal gland) in oncology: 20 years' experience of research on epithalamin].
- Influence of pineal peptides on the dynamics of the circadian and minute motor biorhythms in rats.
- [Function of the pineal body in cancer and aging].
- Chronic administration of pineal peptides change the circadian locomotor activity and time-course of forced swimming in rats.
- [The effect of epiphyseal peptides on the dynamics of the circadian and minute motor biorhythms in rats].
- [Effect of thymalin and epithalamin on the metastasis of experimental tumors irradiated with pulsed laser radiation].
- [Changes in the learning ability of epiphysectomized rats].
- [Pathogenesis and diagnosis of dysovarian cardiomyopathy].
- [Action of a polypeptide epiphyseal extract on cervical cancer].