Condition
Telangiectasia (Spider Veins)
Telangiectasia, often called spider veins, is a widening of tiny blood vessels near the skin's surface that shows up as thin red, purple, or blue lines, and it is usually a cosmetic concern. People most often look at horse chestnut extract and hesperidin/diosmin, which are rated as having moderate evidence, though little research on spider veins specifically has been reviewed here so far. Vitamin C, grape seed extract, bilberry, gotu kola, and rutin have even less behind them, so the evidence there is limited.
- Supplements studied
- 1
- Graded outcomes
- 0
- Trials
- 1
- People studied
- 20
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Erythema | Improves (the measure goes up) | 2 studies | 20 people | |||
The Telangiectasia (Spider Veins) Support protocol
2 primary supplements · 5 supporting supplements
- Horse Chestnut Extract300 mg standardized extract (50 mg aescin) twice daily
- Vitamin C500–1,000 mg daily
Shop the evidence-backed picks
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
We earn from purchases made in our Fullscript store, and links to Fullscript, iHerb or Thorne carry our referral, so we may earn a commission at no extra cost to you. Grades come from the research and never change based on what we earn. Full disclosure
Studies cited
35 studies from PubMed
- Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials
- A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy
- Factors affecting bone loss in female endurance athletes: a two-year follow-up study
- Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women
- Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women
- Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women
- Effect of vitamin K supplementation on bone loss in elderly men and women
- Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women
- Vitamin K, circulating cytokines, and bone mineral density in older men and women
- Effect of continuous combined therapy with vitamin K(2) and vitamin D(3) on bone mineral density and coagulofibrinolysis function in postmenopausal women
- Randomized pilot trial of vitamin K2 for bone loss in patients with primary biliary cirrhosis
- Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials.
- Effect of Vitamin K on Bone Mineral Density and Fracture Risk in Adults: Systematic Review and Meta-Analysis.
- The Efficacy of Vitamin K, A Member Of Naphthoquinones in the Treatment of Cancer: A Systematic Review and Meta-Analysis
- Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: a prospective randomized controlled trial
- The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study
- Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis
- Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population.
- Dietary vitamin K2 supplement improves bone status after lung and heart transplantation
- Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia
- Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG)
- Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age
- Time-dependent effects of vitamin K2 (menatetrenone) on bone metabolism in postmenopausal women
- The effect of vitamin K supplementation on cardiovascular risk factors: a systematic review and meta-analysis.
- Effect of Menaquinone-7 (MK-7) Supplementation on Anthropometric Measurements, Glycemic Indices, and Lipid Profiles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Possible effects of one week vitamin K (menaquinone-4) tablets intake on glucose tolerance in healthy young male volunteers with different descarboxy prothrombin levels
- Effects of topical vitamin K and retinol on laser-induced purpura on nonlesional skin
- The role of topical vitamin K oxide gel in the resolution of postprocedural purpura
- The effects of topical vitamin K on bruising after laser treatment
- Lack of the effect of topical vitamin K on bruising after mechanical injury
- Vitamin K for the primary prevention of cardiovascular disease
- Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis.
- Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials.
- Effect of Vitamin K Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Clinical Trials.
- The relationship between vitamin K and T2DM: a systematic review and meta-analysis.