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Dr. Grey AI

Condition

Telangiectasia (Spider Veins)

Telangiectasia, often called spider veins, is a widening of tiny blood vessels near the skin's surface that shows up as thin red, purple, or blue lines, and it is usually a cosmetic concern. People most often look at horse chestnut extract and hesperidin/diosmin, which are rated as having moderate evidence, though little research on spider veins specifically has been reviewed here so far. Vitamin C, grape seed extract, bilberry, gotu kola, and rutin have even less behind them, so the evidence there is limited.

Supplements studied
1
Graded outcomes
0
Trials
1
People studied
20

Evidence by supplement

  • Strong
  • Moderate
  • Limited
  • Very limited

1 supplement

Vitamin K: outcomes studied for Telangiectasia (Spider Veins)
GradeOutcomeEffectSizeStudiesPeopleStudies list
ErythemaImproves (the measure goes up)2 studies20 people

The Telangiectasia (Spider Veins) Support protocol

2 primary supplements · 5 supporting supplements

See the full protocol

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Studies cited

35 studies from PubMed

  1. Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trialsJ Bone Miner Metab · PMID 21674202
  2. A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapyMaturitas · PMID 10227010
  3. Factors affecting bone loss in female endurance athletes: a two-year follow-up studyAm J Sports Med · PMID 14623654
  4. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal womenOsteoporos Int · PMID 17287908
  5. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese womenJ Bone Miner Metab · PMID 23702931
  6. Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American womenJ Bone Miner Res · PMID 19113922
  7. Effect of vitamin K supplementation on bone loss in elderly men and womenJ Clin Endocrinol Metab · PMID 18252784
  8. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal womenOsteoporos Int · PMID 23525894
  9. Vitamin K, circulating cytokines, and bone mineral density in older men and womenAm J Clin Nutr · PMID 18689371
  10. Effect of continuous combined therapy with vitamin K(2) and vitamin D(3) on bone mineral density and coagulofibrinolysis function in postmenopausal womenMaturitas · PMID 11886767
  11. Randomized pilot trial of vitamin K2 for bone loss in patients with primary biliary cirrhosisJ Hepatol · PMID 11682046
  12. Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials.Osteoporos Int · PMID 31076817
  13. Effect of Vitamin K on Bone Mineral Density and Fracture Risk in Adults: Systematic Review and Meta-Analysis.Biomedicines · PMID 35625785
  14. The Efficacy of Vitamin K, A Member Of Naphthoquinones in the Treatment of Cancer: A Systematic Review and Meta-AnalysisCurr Cancer Drug Targets · PMID 33475062
  15. Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: a prospective randomized controlled trialAnticancer Res · PMID 23225445
  16. The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot studyCancer · PMID 16400650
  17. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosisJ Bone Miner Res · PMID 10750566
  18. Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population.Bone Joint Res · PMID 39657786
  19. Dietary vitamin K2 supplement improves bone status after lung and heart transplantationTransplantation · PMID 20177349
  20. Vitamin K2 treatment for postmenopausal osteoporosis in IndonesiaJ Obstet Gynaecol Res · PMID 16594930
  21. Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG)J Bone Miner Metab · PMID 15616893
  22. Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of ageCalcif Tissue Int · PMID 14506950
  23. Time-dependent effects of vitamin K2 (menatetrenone) on bone metabolism in postmenopausal womenEndocr J · PMID 12201222
  24. The effect of vitamin K supplementation on cardiovascular risk factors: a systematic review and meta-analysis.J Nutr Sci · PMID 38282652
  25. Effect of Menaquinone-7 (MK-7) Supplementation on Anthropometric Measurements, Glycemic Indices, and Lipid Profiles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Prostaglandins Other Lipid Mediat · PMID 40054729
  26. Possible effects of one week vitamin K (menaquinone-4) tablets intake on glucose tolerance in healthy young male volunteers with different descarboxy prothrombin levelsClin Nutr · PMID 10952797
  27. Effects of topical vitamin K and retinol on laser-induced purpura on nonlesional skinDermatol Surg · PMID 10594627
  28. The role of topical vitamin K oxide gel in the resolution of postprocedural purpuraJ Drugs Dermatol · PMID 19894369
  29. The effects of topical vitamin K on bruising after laser treatmentJ Am Acad Dermatol · PMID 12140470
  30. Lack of the effect of topical vitamin K on bruising after mechanical injuryJ Am Acad Dermatol · PMID 15153914
  31. Vitamin K for the primary prevention of cardiovascular diseaseCochrane Database Syst Rev · PMID 26389791
  32. Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis.Diabetes Metab Syndr Obes · PMID 28496349
  33. Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials.Front Nutr · PMID 36704782
  34. Effect of Vitamin K Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Clinical Trials.Horm Metab Res · PMID 29523009
  35. The relationship between vitamin K and T2DM: a systematic review and meta-analysis.Food Funct · PMID 37724446