Supplement
Rutin is a plant bioflavonoid that helps strengthen the walls of tiny blood vessels and makes them less fragile. People mostly look at it for spider veins, though the evidence for that use is limited. In small studies on chronic venous insufficiency, people had modest relief from leg heaviness, cramps and ankle swelling, but it did not make bulging varicose veins disappear.
- Updated
- How we grade
- Best evidence
- Grade C
- Conditions studied
- 4
- Outcomes
- 5
- Graded outcomes
- 0041
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Leg Symptoms Small-moderate improvements in leg heaviness, cramps, swelling (systematic review) | Improves (the measure goes down) | Small effect | 600 people | |||
| Edema Modest reduction in ankle swelling | Improves (the measure goes down) | Small effect | 450 people |
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| LDL Oxidation Inhibits LDL oxidation (mechanism for atherosclerosis prevention) | Improves (the measure goes down) | Small effect | 120 people |
Venous Thromboembolism (Blood Clotting)
- Platelet Aggregation: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Platelet Aggregation Antiplatelet activity via GPIIb/IIIa receptor blocking | Improves (the measure goes down) | Moderate effect | 80 people |
Varicose Veins
- Vein Appearance
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Vein Appearance Does not reverse valve failure or erase bulging veins | NoneNo effect | 200 people |
Key findings
- Leg SymptomsImproves (the measure goes down)
- EdemaImproves (the measure goes down)
- LDL OxidationImproves (the measure goes down)
Shop Rutin
Third-party tested Rutin products. The evidence above is limited, so read it before you buy.
- Grade C
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