Vitamin K2 (MK-7)
Vitamin K2 MK-7 (Menaquinone-7) is the most bioavailable form of vitamin K2, derived from natto (fermented soybeans). Unlike vitamin K1, MK-7 has a long half-life allowing it to reach extrahepatic tissues including bone and vasculature. Clinical trials demonstrate benefits for osteocalcin carboxylation, bone mineral density preservation in postmenopausal women, and arterial stiffness reduction. MK-7 activates proteins (osteocalcin, matrix Gla protein) that direct calcium to bones and away from arteries.
Quick Answer
What it is
Vitamin K2 MK-7 (Menaquinone-7) is the most bioavailable form of vitamin K2, derived from natto (fermented soybeans). Unlike vitamin K1, MK-7 has a long half-life allowing it to reach extrahepatic tissues including bone and vasculature.
Key findings
- Grade A: Osteocalcin Carboxylation (Bone Health)
- Grade B: Bone Mineral Density (Lumbar) (Bone Health)
- Grade B: Matrix Gla Protein Carboxylation (Cardiovascular Health)
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
ℹ️ Quick Facts: Vitamin K2 (MK-7)
Quick Facts: Vitamin K2 (MK-7)
- Best Evidence:Grade A
- Conditions Studied:2
- Research Outcomes:10
- Grade A Findings:1
- Grade B Findings:6
- Key Effect:Bone Health
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (11)
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