Condition
Pathological Gambling (PG)
Gambling disorder is a behavioral addiction in which people keep gambling despite real harm, tied to the brain's dopamine reward pathways and weakened impulse control. Little research on supplements for it has been reviewed here so far, though N-acetyl cysteine has been studied specifically for gambling, and the one review available looks at vitamin D and mental health more broadly. The evidence is moderate for N-acetyl cysteine and limited for everything else.
Sources: PMID 28768407
- Supplements studied
- 1
- Graded outcomes
- 0
- Trials
- 1
- People studied
- 28
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Impulse Control | Improves (the measure goes up) | 1 study | 28 people | |||
Studies that measured impulse control | ||||||
The Gambling Disorder Recovery Support protocol
2 primary supplements · 7 supporting supplements
- N-Acetyl Cysteine (NAC)1,200–1,800 mg daily in divided doses
- Omega-3 Fatty Acids2–3 g EPA+DHA daily
Studies cited
11 studies from PubMed
- The inhibitory effects of nicotine on physiological sexual arousal in nonsmoking women: results from a randomized, double-blind, placebo-controlled, cross-over trial
- Effects of intravenous cocaine and cigarette smoking on luteinizing hormone, testosterone, and prolactin in men
- Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial
- Nicotine increases neural response to unpleasant stimuli and anxiety in non-smokers
- Nicotine differentially modulates antisaccade performance in healthy male non-smoking volunteers stratified for low and high accuracy
- Acute effects of nicotine on physiological and subjective sexual arousal in nonsmoking men: a randomized, double-blind, placebo-controlled trial
- Acute effects of nicotine on serum glucose insulin growth hormone and cortisol in healthy smokers
- Nicotine infusion acutely impairs insulin sensitivity in type 2 diabetic patients but not in healthy subjects
- Preliminary findings on the interactive effects of IV ethanol and IV nicotine on human behavior and cognition: a laboratory study
- Effect of chewing gum containing nicotine and caffeine on energy expenditure and substrate utilization in men
- The effects of acute doses of nicotine on video lottery terminal gambling in daily smokers