Condition
Hyperemesis Gravidarum
Hyperemesis gravidarum is severe nausea and vomiting in pregnancy that goes beyond typical morning sickness, causing dehydration, weight loss and electrolyte imbalances. Vitamin B6 and ginger have the strongest evidence among supplements, and in nine ginger studies involving 321 people, nausea symptoms eased. Those studies were small, and the evidence for ginger was moderate, so how well it works in the most severe cases remains unclear.
Sources: PMID 24642205; PMID 11275030
- Supplements studied
- 1
- Graded outcomes
- 1
- Trials
- 2
- People studied
- 321
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Nausea Symptoms Moderate Improvement | Improves (the measure goes down) | Moderate effect | 9 studies | 321 people | ||
Key findings
- Nausea SymptomsImproves (the measure goes down)
The Hyperemesis Gravidarum Supportive Care protocol
2 primary supplements · 7 supporting supplements
- Vitamin B6 (Pyridoxine)10–25 mg three times daily
- Ginger250 mg four times daily or 1 g daily total
Studies cited
38 studies from PubMed
- Ginger for treating nausea and vomiting: an overview of systematic reviews and meta-analyses
- Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
- Effects of Ginger Intake on Chemotherapy-Induced Nausea and Vomiting: A Systematic Review of Randomized Clinical Trials
- Efficacy of Ginger (Zingiber officinale) in Ameliorating Chemotherapy-Induced Nausea and Vomiting and Chemotherapy-Related Outcomes: A Systematic Review Update and Meta-Analysis
- Does the Oral Administration of Ginger Reduce Chemotherapy-Induced Nausea and Vomiting?: A Meta-analysis of 10 Randomized Controlled Trials
- The effectiveness and safety of ginger for pregnancy-induced nausea and vomiting: a systematic review
- A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting
- Effects of ginger for nausea and vomiting in early pregnancy: a meta-analysis
- Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: a systematic literature review
- Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials
- Effects of ginger on motion sickness susceptibility and gastric function
- Acute effects of dietary ginger on quadriceps muscle pain during moderate-intensity cycling exercise
- Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise
- Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: a pilot study
- Effect of ginger on lower esophageal sphincter pressure
- Effects of ginger on gastric emptying and motility in healthy humans
- Ginger syrup as an antiemetic in early pregnancy
- Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial
- Effect of a ginger extract on pregnancy-induced nausea: a randomised controlled trial
- Effectiveness of ginger for prevention of nausea and vomiting after gynecological laparoscopy
- The efficacy of ginger in prevention of postoperative nausea and vomiting after major gynecologic surgery
- The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis
- Vertigo-reducing effect of ginger root. A controlled clinical study
- A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy
- Ginger treatment of hyperemesis gravidarum
- Comparing analgesic effects of a topical herbal mixed medicine with salicylate in patients with knee osteoarthritis
- A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis
- Effectiveness and safety of steamed ginger extract on mild osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial.
- Anti-emetic effect of ginger powder versus placebo as an add-on therapy in children and young adults receiving high emetogenic chemotherapy
- Effect of ginger on gastric motility and symptoms of functional dyspepsia
- Zingiber officinale Improves Cognitive Function of the Middle-Aged Healthy Women
- Phase II study of the effects of ginger root extract on eicosanoids in colon mucosa in people at normal risk for colorectal cancer
- Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial
- Ginger extract reduces delayed gastric emptying and nosocomial pneumonia in adult respiratory distress syndrome patients hospitalized in an intensive care unit
- Effect of treatment with ginger on the severity of premenstrual syndrome symptoms
- Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea
- The effect of oral supplementation of ginger on glycemic control of patients with type 2 diabetes mellitus - A systematic review and meta-analysis.
- Beneficial Effects of Ginger Extract on Eye Fatigue and Shoulder Stiffness: A Randomized, Double-Blind, and Placebo-Controlled Parallel Study.