Condition
Amyotrophic Lateral Sclerosis
ALS, sometimes called Lou Gehrig's disease, is a progressive condition in which motor neurons, the nerve cells that control voluntary muscles, die, leading to weakness, muscle wasting, and eventually paralysis. Creatine has the most human trial data: six studies with 386 people found no clear difference in ALS symptoms. The evidence is very limited overall, and one mouse study of 7,8-dihydroxyflavone that preserved motor performance says little about people.
Sources: PMID 23235621; PMID 11677005
- Supplements studied
- 3
- Graded outcomes
- 2
- Trials
- 6
- People studied
- 842
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Motor Neuron Degeneration (ALS) In SOD1-G93A transgenic mice (ALS model), the 7,8-DHF prodrug R13 preserved motor performance by improving mitochondrial function. This represents a single preclinical study in one ALS mouse model. | Improves (the measure goes down) | Small effect | 1 study | |||
Studies that measured motor neuron degeneration (als) | ||||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| ALS Symptoms | Improves (the measure goes down) | 1 study | 34 people | |||
Studies that measured als symptoms | ||||||
Key findings
- Amyotrophic Lateral Sclerosis Symptoms
- Motor Neuron Degeneration (ALS)Improves (the measure goes down)
The ALS Supportive Care protocol
2 primary supplements · 6 supporting supplements
- Vitamin D2,000–5,000 IU daily (target 40–60 ng/mL, monitor levels)
- Coenzyme Q10300–1,200 mg daily in divided doses
Studies cited
100 studies from PubMed
- 7,8-Dihydroxyflavone protects acetaminophen induced liver injury through activating PI3K/Akt/NRF2/GPX4 mediated ferroptosis suppression
- Oral 7,8-Dihydroxyflavone Protects Retinal Ganglion Cells by Modulating the Gut-Retina Axis and Inhibiting Ferroptosis via the Indoleacrylic Acid-AhR-ALDH1A3-FSP1 Pathway
- 7,8-Dihydroxyflavone attenuates cisplatin-induced cardiomyocyte apoptosis and mitochondrial dysfunction via the p53/Nrf2 pathway
- 7,8-Dihydroxyflavone ameliorates cognitive impairment induced by repeated neonatal sevoflurane exposures in mice through increasing tau O-GlcNAcylation
- 7, 8-dihydroxyflavone Ameliorates Cholinergic Dysfunction, Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Vascular Dementia
- 7,8-DHF inhibits BMSC oxidative stress via the TRKB/PI3K/AKT/NRF2 pathway to improve symptoms of postmenopausal osteoporosis
- 7,8-dihydroxyflavone displayed antioxidant effect through activating HO-1 expression and inhibiting caspase-3/PARP activation in RAW264.7 cells
- 7,8-dihydroxyflavone reduces lipid peroxidation, proinflammatory cytokines, and mediators in chemically induced phenylketonuria model
- Investigating 7,8-Dihydroxyflavone to combat maternal immune activation effects on offspring gene expression and behaviour
- 7,8-dihydroxyflavone enhances long-term spatial memory and alters brain volume in wildtype mice
- 7,8-Dihydroxyflavone alleviates cardiac fibrosis by restoring circadian signals via downregulating Bmal1/Akt pathway
- BDNF mimetic 7,8-dihydroxyflavone rescues rotenone-induced cytotoxicity in cardiomyocytes by ameliorating mitochondrial dysfunction
- 7,8-Dihydroxyflavone Attenuates Inflammatory Response and Insulin Resistance Induced by the Paracrine Interaction between Adipocytes and Macrophages
- Early 7,8-Dihydroxyflavone Administration Ameliorates Synaptic and Behavioral Deficits in the Young FXS Animal Model by Acting on BDNF-TrkB Pathway
- Treatment with the flavonoid 7,8-Dihydroxyflavone: a promising strategy for a constellation of body and brain disorders
- 7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1-103 transgenic mice
- 7,8-Dihydroxyflavone protects retinal ganglion cells against chronic intermittent hypoxia-induced oxidative stress damage via activation of the BDNF/TrkB signaling pathway
- 7,8-Dihydroxyflavone alleviates apoptosis and inflammation induced by retinal ischemia-reperfusion injury via activating TrkB/Akt/NF-kB signaling pathway
- TrkB Receptor Agonist 7,8 Dihydroxyflavone is Protective Against the Inner Retinal Deficits Induced by Experimental Glaucoma
- Small-molecule 7,8-dihydroxyflavone counteracts compensated and decompensated cardiac hypertrophy via AMPK activation
- 7,8-Dihydroxyflavone alleviates Endoplasmic Reticulum Stress in cafeteria diet-induced metabolic syndrome
- Metabolic protection by the dietary flavonoid 7,8-dihydroxyflavone requires an intact gut microbiome
- Low-dose 7,8-Dihydroxyflavone Administration After Status Epilepticus Prevents Epilepsy Development
- 7,8-Dihydroxyflavone protects neurons against oxygen-glucose deprivation induced apoptosis and activates the TrkB/Akt pathway
- 7,8-Dihydroxyflavone accelerates recovery of Brown-Sequard syndrome in adult female rats with spinal cord lateral hemisection
- Utility of 7,8-dihydroxyflavone in preventing astrocytic and synaptic deficits in the hippocampus elicited by PTSD
- 7,8-Dihydroxyflavone Simultaneously Provides Neuroprotection of Retinal Explants and Proangiogenesis of Human Umbilical Vein Endothelial Cells via the Tropomyosin-Related Kinase Receptor B Signaling Pathway In Vitro
- Does creatine supplementation improve glycemic control and insulin resistance in healthy and diabetic patients? A systematic review and meta-analysis.
- 7,8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer's disease by reversing oxidative stress, mitochondrial dysfunction, and insulin resistance
- 7,8-Dihydroxyflavone Alleviates Anxiety-Like Behavior Induced by Chronic Alcohol Exposure in Mice Involving Tropomyosin-Related Kinase B in the Amygdala
- 7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis
- The TrkB agonist, 7,8-dihydroxyflavone, impairs fracture healing in mice
- Sex-Dependent Effects of 7,8-Dihydroxyflavone on Metabolic Health Are Associated with Alterations in the Host Gut Microbiome
- R13 preserves motor performance in SOD1(G93A) mice by improving mitochondrial function
- 7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence
- 7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents
- 7,8-Dihydroxyflavone Protects High Glucose-Damaged Neuronal Cells against Oxidative Stress
- 7,8-Dihydroxyflavone potentiates ongoing epileptiform activity in mice brain slices
- 7,8-Dihydroxyflavone activates Nrf2/HO-1 signaling pathways and protects against osteoarthritis
- A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model
- 7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders
- 7,8-Dihydroxyflavone reverses the depressive symptoms in mouse chronic mild stress
- 7, 8-Dihydroxyflavone Protects an Endothelial Cell Line from H2O2 Damage
- 7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss
- 7,8-Dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine
- 7,8-dihydroxyflavone ameliorates scopolamine-induced Alzheimer-like pathologic dysfunction
- O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity
- Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning
- A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
- Role of creatine supplementation on exercise-induced cardiovascular function and oxidative stress
- Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players
- Does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training
- Effects of creatine supplementation on glucose tolerance and insulin sensitivity in sedentary healthy males undergoing aerobic training
- Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle
- Creatine supplementation affects glucose homeostasis but not insulin secretion in humans
- Creatine supplementation and health variables: a retrospective study
- Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization
- Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle
- Effect of creatine monohydrate in improving cellular energetics and muscle strength in ambulatory Duchenne muscular dystrophy patients: a randomized, placebo-controlled 31P MRS study
- Creatine for treating muscle disorders.
- Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy
- Comparison of creatine ingestion and resistance training on energy expenditure and limb blood flow
- Creatine, arginine alpha-ketoglutarate, amino acids, and medium-chain triglycerides and endurance and performance
- The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels
- Effect of in-season creatine supplementation on body composition and performance in rugby union football players
- Creatine fails to augment the benefits from resistance training in patients with HIV infection: a randomized, double-blind, placebo-controlled study
- Effect of creatine and weight training on muscle creatine and performance in vegetarians
- Effects of creatine supplementation in taekwondo practitioners
- Creatine supplementation improves muscular performance in older women
- The effects of creatine monohydrate supplementation with and without D-pinitol on resistance training adaptations
- Effects of creatine on body composition and strength gains after 4 weeks of resistance training in previously nonresistance-trained humans
- Creatine monohydrate supplementation on body weight and percent body fat
- Reliability and detecting change following short-term creatine supplementation: comparison of two-component body composition methods
- Low-dose creatine supplementation enhances fatigue resistance in the absence of weight gain
- Efficacy of Creatine Supplementation Combined with Resistance Training on Muscle Strength and Muscle Mass in Older Females: A Systematic Review and Meta-Analysis.
- The Paradoxical Effect of Creatine Monohydrate on Muscle Damage Markers: A Systematic Review and Meta-Analysis
- Creatine supplementation and physical training in patients with COPD: a double blind, placebo-controlled study
- Creatine monohydrate increases strength in patients with neuromuscular disease
- Effect of creatine ingestion after exercise on muscle thickness in males and females
- Does nutritional supplementation influence adaptability of muscle to resistance training in men aged 48 to 72 years
- Effects of four weeks of high-intensity interval training and creatine supplementation on critical power and anaerobic working capacity in college-aged men
- Effect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletes
- Effect of short-term creatine supplementation on neuromuscular function
- The effects of polyethylene glycosylated creatine supplementation on muscular strength and power
- Effect of thirty days of creatine supplementation with phosphate salts on anaerobic working capacity and body weight in men
- The effects of supplementation with creatine and protein on muscle strength following a traditional resistance training program in middle-aged and older men
- The effects of pre versus post workout supplementation of creatine monohydrate on body composition and strength
- Effect of different frequencies of creatine supplementation on muscle size and strength in young adults
- Effects of creatine monohydrate and polyethylene glycosylated creatine supplementation on muscular strength, endurance, and power output
- The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching
- Creatine as a metabolic controller of skeletal muscles structure and function in strength exercises in humans
- Effects of creatine monohydrate supplementation on body composition and strength indices in experienced resistance trained women
- Effects of oral creatine and resistance training on serum myostatin and GASP-1
- Effects of two and five days of creatine loading on muscular strength and anaerobic power in trained athletes
- Effects of high dose oral creatine supplementation on anaerobic capacity of elite wrestlers
- The effects of four weeks of creatine supplementation and high-intensity interval training on cardiorespiratory fitness: a randomized controlled trial
- Effect of caffeine ingestion after creatine supplementation on intermittent high-intensity sprint performance
- Effects of creatine supplementation and three days of resistance training on muscle strength, power output, and neuromuscular function
- Mg2+-creatine chelate and a low-dose creatine supplementation regimen improve exercise performance
- Physiological responses to short-term exercise in the heat after creatine loading