Supplement
Violet flower is the blossom of sweet violet, a plant used in traditional herbal remedies and rich in anthocyanin pigments and coumarin compounds with antioxidant and anti-inflammatory properties. People mostly look at it for cough, and in a double-blind trial of 182 children with asthma, coughing eased faster with violet syrup than with placebo alongside usual asthma medicine. Still, the evidence is limited, and other studies were small or lab-based.
Sources: PMID 25954025
- Updated
- How we grade
- 8 studies cited
- Best evidence
- Grade C
- Conditions studied
- 3
- Outcomes
- 6
- Graded outcomes
- 0024
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Allergic Rhinitis Symptoms A double-blind randomized placebo-controlled clinical trial found that Viola odorata flower oil had significant positive effects on allergic rhinitis symptoms in adults, though the authors noted the study was preliminary and larger trials are needed. | Improves (the measure goes down) | Small effect | 2 studies | 50 people | ||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Asthma-Related Cough A double-blind RCT in 182 children (ages 2-12) with intermittent asthma found that violet syrup as an adjunct to short-acting beta-agonist achieved 50% cough reduction and 100% cough suppression significantly faster than placebo (P<0.001). | Improves (the measure goes down) | Moderate effect | 2 studies | 182 people | ||
General
- Antioxidant Activity: improves
- Fever: improves
- Insomnia: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Antioxidant Activity In vitro analysis found sweet violet flowers had the highest anthocyanin concentration (99.41 mg/100g) among tested edible flowers but relatively modest overall antioxidant capacity. Coumarin derivatives (umbelliferone, esculetin) with known anti-inflammatory and antioxidant properties were also identified. | Improves (the measure goes up) | Small effect | 3 studies | |||
Studies that measured antioxidant activity
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| Fever A triple-blinded placebo-controlled RCT in 41 febrile neutropenic children with cancer found topical Viola odorata oil significantly reduced temperature at 30 minutes (P=0.005) and reduced rescue paracetamol use (5 vs 17 patients, P=0.001). | Improves (the measure goes down) | Small effect | 2 studies | 41 people | ||
| Insomnia An uncontrolled pre-post study in 50 patients with chronic insomnia found intranasal violet oil drops reduced Insomnia Severity Index scores from 16.32 to 6.48 over one month (P<0.05). However, the lack of a control group limits interpretation. | Improves (the measure goes down) | Moderate effect | 2 studies | 50 people | ||
Acute Respiratory Infection (ARI)
- Respiratory Infection Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Respiratory Infection Symptoms A randomized double-blind controlled trial in 108 COVID-19 outpatients found that add-on violet syrup significantly improved cough (P=0.025), myalgia (P=0.036), and headache (P=0.037) over 7 days compared to standard care alone. | Improves (the measure goes down) | Small effect | 2 studies | 108 people | ||
Studies that measured respiratory infection symptoms | ||||||
Key findings
- Allergic Rhinitis SymptomsImproves (the measure goes down)
- Asthma-Related CoughImproves (the measure goes down)
- Antioxidant ActivityImproves (the measure goes up)
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- Grade C
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Studies cited
8 studies from PubMed
- Efficacy and safety of add-on Viola odorata L. in the treatment of COVID-19: A randomized double-blind controlled trial
- Detection of Coumarin Derivatives of Viola odorata Cultivated in Iraq
- Impact of Drying Conditions on Antioxidant Activity of Red Clover (Trifolium pratense), Sweet Violet (Viola odorata) and Elderberry Flowers (Sambucus nigra)
- Efficacy of Sweet Violet (Viola odorata) flower oil on the symptoms of adults with allergic rhinitis: A double-blind randomized placebo-controlled clinical trial
- The Effect of Viola Odorata L. Oil for Fever in Children: A Randomized Triple-blinded Placebo-controlled Clinical Trial
- Analysis of Almond-Violet Oil by Gas Chromatography (A Traditional Formula)
- The Effect of Viola odorata Flower Syrup on the Cough of Children With Asthma: A Double-Blind, Randomized Controlled Trial
- Efficacy of Viola odorata in Treatment of Chronic Insomnia