Supplement
Oxiracetam is a lab-made compound from the racetam family that is thought to influence AMPA receptors, which help nerve cells signal to each other and form memories. People mostly look at it for dementia, and across four small studies the evidence was moderate that cognitive decline improved. A separate look at day-to-day functioning found no clear difference, and that evidence is very limited, so the picture is far from settled.
Sources: PMID 2521069; PMID 2781039
- Updated
- How we grade
- 5 studies cited
- Best evidence
- Grade B
- Conditions studied
- 5
- Outcomes
- 10
- Graded outcomes
- 0111
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cognitive Decline Small Improvement | Improves (the measure goes down) | Small effect | 4 studies | 415 people | ||
Studies that measured cognitive decline
| ||||||
| Functionality in Elderly or Injured No effect | NoneNo effect | 73 people | ||||
| Memory | Improves (the measure goes up) | 272 people | ||||
| Quality of Life | Improves (the measure goes up) | 58 people | ||||
| Verbal Fluency | Improves (the measure goes up) | 131 people | ||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cognitive Decline Small Improvement | Improves (the measure goes down) | Small effect | 4 studies | 60 people | ||
Studies that measured cognitive decline
| ||||||
| Memory | Improves (the measure goes up) | 60 people | ||||
Alzheimer’s Disease
- Alzheimer's Disease Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Alzheimer's Disease Symptoms | Improves (the measure goes down) | 1 study | 24 people | |||
Studies that measured alzheimer's disease symptoms | ||||||
Cognitive Improvement
- Alzheimer's Disease Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Alzheimer's Disease Symptoms | Improves (the measure goes down) | 1 study | 24 people | |||
Studies that measured alzheimer's disease symptoms | ||||||
Alzheimer’s Disease
- Alzheimer's Disease Symptoms: changes; see studies
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Alzheimer's Disease Symptoms | Changes; see studies | 1 study | 24 people | |||
Studies that measured alzheimer's disease symptoms | ||||||
Key findings
- Cognitive DeclineImproves (the measure goes down)
- Functionality in Elderly or Injured
Shop the evidence-backed picks
Third-party tested Oxiracetam products, in the forms the graded studies used where we can match them.
- Grade B
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Studies cited
5 studies from PubMed
- Oxiracetam in the treatment of multi-infarct dementia and primary degenerative dementia
- Oxiracetam in the treatment of multi-infarct dementia
- Oxiracetam in dementia: a double-blind, placebo-controlled study
- Oxiracetam in the treatment of primary degenerative and multi-infarct dementia: a double-blind, placebo-controlled study
- Treatment trial of oxiracetam in Alzheimer's disease