Kanna
Kanna is a South African succulent with unique dual mechanism: serotonin reuptake inhibition (SSRI-like) + PDE4 inhibition. Active alkaloids include mesembrine, mesembrenone, mesembrenol. Brain imaging shows reduced amygdala reactivity to threat (anxiolytic mechanism). Small trials show cognitive/mood benefits. CRITICAL: Do NOT combine with SSRIs, SNRIs, or MAOIs - serotonin syndrome risk. Not addictive. Standardized extract (Zembrin) used at 25mg daily.
Quick Answer
What it is
Kanna is a South African succulent with unique dual mechanism: serotonin reuptake inhibition (SSRI-like) + PDE4 inhibition. Active alkaloids include mesembrine, mesembrenone, mesembrenol.
Key findings
- Grade C: Cognition (Cognitive Improvement)
- Grade C: Executive Function (Cognitive Improvement)
- Grade D: Reaction Time (Stress)
Safety
- CRITICAL: Do NOT combine with SSRIs, SNRIs, or MAOIs - serotonin syndrome risk.
ℹ️ Quick Facts: Kanna
Quick Facts: Kanna
- Best Evidence:Grade C
- Conditions Studied:5
- Research Outcomes:28
- Key Effect:Cognitive Improvement
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (3)
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