Dr. Grey AI

Muira puama

Muira puama is a Brazilian herb traditionally used as an aphrodisiac and nerve tonic. The nickname 'Potency Wood' reflects its traditional sexual health use, but human evidence for sexual benefits is weak. Interestingly, preliminary research suggests it may be effective as a COGNITIVE ENHANCER rather than an aphrodisiac. Contains lupeol and other triterpenoids. NO GRADED OUTCOMES - lacks quality human trials for either sexual or cognitive claims. The cognitive enhancement angle warrants more research.

Quick Answer

What it is

Muira puama is a Brazilian herb traditionally used as an aphrodisiac and nerve tonic. The nickname 'Potency Wood' reflects its traditional sexual health use, but human evidence for sexual benefits is weak.

Key findings

  • Grade C: Cognitive Function
  • Grade D: Neuroprotection
  • Grade D: Libido and Sexual Function

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Muira puama

Quick Facts: Muira puama

  • Best Evidence:Grade C
  • Conditions Studied:4
  • Research Outcomes:6
  • Key Effect:Age-Associated Memory Impairment and Cognitive Decline (AAMCD)
Outcomes by grade:
A0
B0
C1
D5
4 conditions · 6 outcomes

Detailed Outcomes

|
C
Cognitive Function
In rodent models, P. olacoides extract consistently improved memory retrieval in step-down avoidance and object recognition tasks in both young and aged mice across multiple studies. Effects are mediated through acetylcholinesterase inhibition (15-33% in hippocampus) and serotonin 5-HT2A receptor modulation. No human cognitive trials exist.
moderate↑Improves
D
Neuroprotection
In preclinical models, P. olacoides extract protected rat hippocampal slices from oxygen-glucose deprivation, reduced brain lipid peroxidation and free radical production in aged mice, and prevented amyloid-beta(1-42)-induced cognitive impairment and amyloid deposits in a mouse Alzheimer's model. All studies from a single research group.
moderate↑Improves
D
Libido and Sexual Function
Three open-label, uncontrolled human studies reported improvements in self-reported libido and sexual function (62% of 262 men reported a 'dynamic effect'; 85% of 26 men reported improved libido). The largest study (202 women) used a combination product with Ginkgo biloba. All lacked placebo controls and blinding.
small↑Improves
D
Depressive Symptoms
In a mouse forced swim test, P. olacoides extract (15-100 mg/kg i.p. and 300 mg/kg oral) produced dose-related anti-immobility effects mediated through beta-adrenergic and dopamine D1 receptor pathways. No human antidepressant trials have been conducted.
small↓Improves
D
Brain Antioxidant Status
In aged mice, P. olacoides extract (100 mg/kg) reduced free radical production in hypothalamus, decreased lipid peroxidation across multiple brain regions, and increased catalase and glutathione peroxidase activity in hippocampus and cortex.
moderate↑Improves
D
Stress Resilience
In a mouse unpredictable chronic mild stress model, P. olacoides extract prevented stress-induced anxiety-like behavior and hyperglycemia, suggesting adaptogen-like properties. Notably, it did not produce direct anxiolytic effects in unstressed animals.
small↑Worsens

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