Dr. Grey AI

Bromantane

Bromantane (Ladasten) is a synthetic adamantane derivative with a unique dual anxiolytic-actoprotective profile. It enhances dopamine synthesis by upregulating tyrosine hydroxylase and aromatic L-amino acid decarboxylase gene expression, rather than inhibiting reuptake. Approved in Russia for neurasthenia; banned by WADA as a stimulant.

Quick Answer

What it is

Bromantane (Ladasten) is a synthetic adamantane derivative with a unique dual anxiolytic-actoprotective profile. It enhances dopamine synthesis by upregulating tyrosine hydroxylase and aromatic L-amino acid decarboxylase gene expression, rather than inhibiting reuptake.

Key findings

  • Grade B: Asthenia Symptoms (Neurasthenia)
  • Grade C: Anxiety Symptoms (Anxiety Disorders (Other))
  • Grade C: Physical Work Capacity (Primarily Preclinical) (General Athletic Performance)

Safety

  • This supports short-term tolerability but does not establish long-term dependence risk.
ℹ️ Quick Facts: Bromantane

Quick Facts: Bromantane

  • Best Evidence:Grade B
  • Conditions Studied:7
  • Research Outcomes:6
  • Grade B Findings:1
  • Key Effect:Neurasthenia
Outcomes by grade:
A0
B1
C4
D1
7 conditions · 6 outcomes

Detailed Outcomes

|
B
Asthenia Symptoms
PubMed-indexed clinical studies report anti-asthenic effects of bromantane in neurasthenia/psychogenic asthenia. A multicenter open-label study (n=76; PMID: 20559263) and a multicenter double-blind placebo-controlled study (n=156; PMID: 21322821) reported reduced asthenic symptoms with 50-100 mg/day for 28 days. An additional clinical report (PMID: 19491814) is directionally consistent.
moderate↓Improves
C
Anxiety Symptoms
Anxiolytic effects are supported by one placebo-controlled asthenia trial showing reduced anxiety symptoms (PMID: 21322821), a supporting clinical report (PMID: 19491814), and rat behavioral data showing anxiolytic effects without prominent locomotor stimulation at tested doses (PMID: 16047669). Clinical anxiety-specific RCT data remain limited.
small↓Improves
C
Physical Work Capacity (Primarily Preclinical)
Evidence for improved physical work capacity is mostly preclinical. Animal studies under repeated extreme exercise conditions reported higher work capacity with bromantane (PMID: 9929819; PMID: 10934588). A human operator study reported improved psychophysiological restoration under fatigue conditions versus placebo (PMID: 10998997), but evidence remains limited for general athletic performance.
moderate↑Improves
C
Dependence/Withdrawal Signs (Short-Term)
Short-term clinical studies (up to 28 days) reported no clear withdrawal syndrome or addiction-like signs after bromantane treatment in asthenic populations (PMID: 19491814; PMID: 20559263; PMID: 21322821). This supports short-term tolerability but does not establish long-term dependence risk.
none
C
Dopamine Synthesis (TH/AADC Expression)
Preclinical rat studies indicate bromantane upregulates dopamine synthesis machinery. Repeated administration increased tyrosine hydroxylase and/or aromatic L-amino acid decarboxylase expression in dopaminergic regions (PMID: 15500036) and altered striatal dopamine synthesis/catabolism (PMID: 7580761). Evidence is mechanistic and animal-based.
moderate↑Improves
D
Cognitive/Psychomotor Performance
Limited human experimental data suggest bromantane may improve selected psychophysiological or operator-performance measures under fatigue (PMID: 10998997) and modulate EEG rhythms consistent with CNS activation (PMID: 19642584). Evidence is preliminary and not based on large cognitive endpoint trials.
small↑Improves

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