Protocol · Women's Health/Endocrine
Primary Ovarian Insufficiency Support Protocol
Vitamin D and Calcium are the core of this stack, with 4 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Primary Ovarian Insufficiency Support.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
6 supplements · none graded yet
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Vitamin D | Amount listed: 2,000–4,000 IU daily (titrate to levels) | Critical for bone health; POI increases osteoporosis risk; often deficient | Not graded yet | ||
| Calcium | Amount listed: 1,000–1,200 mg daily (diet + supplement) | Essential for bone health; estrogen deficiency accelerates bone loss | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| DHEA | Amount listed: 25–75 mg daily (under medical supervision) | May support ovarian function and improve fertility outcomes in some cases | Not graded yet | ||
| Coenzyme Q10 | Amount listed: 200–600 mg daily | Supports mitochondrial function in oocytes; being studied for fertility | Not graded yet | ||
| Omega-3 Fatty Acids | Amount listed: 2–3 g EPA+DHA daily | Cardiovascular protection; estrogen deficiency increases CV risk | Not graded yet | ||
| Magnesium | Amount listed: 300–400 mg daily | Supports bone health; may help with mood and sleep disturbances | Not graded yet | ||
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Primary Ovarian Insufficiency. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
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How this protocol works
In plain language
Primary Ovarian Insufficiency (POI), previously called premature ovarian failure, occurs when the ovaries stop functioning normally before age 40. This leads to irregular periods, low estrogen, and often infertility.
KEY FEATURES:
- Occurs before age 40
- Irregular or absent periods
- Symptoms of estrogen deficiency (hot flashes, vaginal dryness)
- Elevated FSH levels (>25 IU/L on two occasions)
- Reduced fertility (though spontaneous pregnancy possible in ~5%)
CAUSES:
- Unknown in most cases (idiopathic)
- Genetic conditions (Turner syndrome, Fragile X carrier)
- Autoimmune disorders
- Chemotherapy or radiation
- Surgical removal of ovaries
CRITICAL: POI requires medical management for hormone replacement and associated health risks. This protocol is SUPPORTIVE ONLY.
MEDICAL MANAGEMENT:
- Hormone replacement therapy (HRT): Essential until typical menopause age
- Estrogen + progesterone: Protects bone, heart, brain, vaginal health
- Fertility options: Egg donation most successful; IVF with own eggs sometimes possible
- Bone health monitoring: DEXA scan; prevent osteoporosis
- Cardiovascular risk: Monitor lipids, blood pressure
LONG-TERM HEALTH CONCERNS:
- Osteoporosis (early estrogen loss damages bones)
- Cardiovascular disease (estrogen is protective)
- Cognitive effects
- Sexual and vaginal health
- Emotional impact
Vitamin D and calcium* are critical for bone health.
DHEA* may support ovarian function (discuss with specialist).
Cardiovascular protection* with omega-3 and healthy lifestyle.
Expected timeline: HRT provides immediate symptom relief. Bone and cardiovascular protection requires ongoing management. Supplements support overall health alongside HRT.