Protocol · Men's Health
Peyronie's Disease Supportive Care Protocol
Coenzyme Q10 and Vitamin E are the core of this stack, with 5 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Peyronie's Disease Supportive Care.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
7 supplements · 1 graded
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Coenzyme Q10 | Amount listed: 200–300 mg daily | Antioxidant that may reduce oxidative stress contributing to plaque formation
| Grade C for Erections186 people | ||
| Vitamin E | Amount listed: 400–800 IU daily | Classic antioxidant therapy for PD; may reduce plaque progression | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| L-Carnitine | Amount listed: 1–2 g acetyl-L-carnitine daily | Shown to reduce plaque size and curvature in studies; supports tissue healing | Not graded yet | ||
| Omega-3 Fatty Acids | Amount listed: 2–3 g EPA+DHA daily | Anti-inflammatory effects may help reduce fibrosis progression | Not graded yet | ||
| Potassium Para-aminobenzoate (PABA) | Amount listed: 3 g four times daily (12 g total) - high doses needed | May have anti-fibrotic effects; historically used for fibrotic conditions | Not graded yet | ||
| Collagen Peptides | Amount listed: 5–10 g daily | May support tissue remodeling and healing | Not graded yet | ||
| Zinc | Amount listed: 25–50 mg daily | Supports wound healing and tissue repair | Not graded yet | ||
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Peyronie's Disease. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
- Grade C
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How this protocol works
In plain language
Peyronie's disease (PD) is a condition where scar tissue (plaque) forms in the penis, causing curvature, pain, and erectile dysfunction. It typically begins after minor trauma to the penis during sex. The scar tissue forms as part of abnormal wound healing in genetically susceptible individuals. PD has two phases: the acute/active phase (pain, plaque forming, curvature worsening) lasting 6-18 months, and the stable/chronic phase (pain resolves, plaque and curvature stabilize). About 10% of men are affected.
CRITICAL: Peyronie's disease treatment depends on the phase and severity. In the acute phase, conservative management (supplements, traction devices) may help limit progression. In the stable phase with significant deformity, medical and surgical options include: intralesional injections (collagenase/Xiaflex, verapamil), traction therapy, and surgery (plication, grafting, implants). See a urologist who specializes in PD. Supplements may provide modest benefit but won't reverse established plaques. Evidence for most supplements is limited. Sexual counseling and psychological support are important components of care.
Coenzyme Q10* has shown the most promise in clinical trials, with one study showing reduced curvature progression and plaque size compared to placebo.
Vitamin E* is the most traditionally used supplement for PD, though evidence is actually limited. It's thought to work through antioxidant effects. Often combined with other treatments.
Acetyl-L-Carnitine* has shown benefit in some studies, with effects on pain, curvature, and plaque size comparable to or better than vitamin E.
Omega-3 Fatty Acids* may help through anti-inflammatory and anti-fibrotic effects.
PABA (Potassium Para-aminobenzoate)* has been used historically for fibrotic conditions. High doses are needed, which can cause GI side effects.
Collagen and Zinc* support tissue healing in general.
Expected timeline: PD natural history: acute phase 6-18 months, then stabilizes. Supplements are most likely to help during the acute phase when plaque is still forming. Allow 3-6 months to assess benefit. Surgery is reserved for stable disease with significant deformity.