Protocol · Neurological Health
Organic Brain Syndrome Supportive Care Protocol
Omega-3 Fatty Acids and Vitamin B12 are the core of this stack, with 8 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Organic Brain Syndrome Supportive Care.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
10 supplements · none graded yet
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file |
|---|---|---|---|---|
| Primary stackThe core of this protocol | ||||
| Omega-3 Fatty Acids | Amount listed: 2–4 g EPA+DHA daily | Supports brain structure and function; anti-inflammatory; may help cognitive function | Not graded yet | |
| Vitamin B12 | Amount listed: 1,000–2,000 mcg methylcobalamin daily (or injection if absorption issue) | Deficiency is common cause of reversible cognitive impairment; essential for nerve function | Not graded yet | |
| Supporting stackListed as additions to the core | ||||
| Vitamin D | Amount listed: 2,000–4,000 IU daily | Deficiency linked to cognitive decline; neuroprotective effects | Not graded yet | |
| Ginkgo Biloba | Amount listed: 120–240 mg standardized extract daily | Improves cerebral blood flow; antioxidant; studied for cognitive impairment | Not graded yet | |
| Citicoline (CDP-Choline) | Amount listed: 500–2,000 mg daily | Supports brain cell membrane repair; enhances acetylcholine; studied for cognitive disorders | Not graded yet | |
| Folate | Amount listed: 400–800 mcg methylfolate daily | Works with B12; deficiency can cause cognitive impairment; important for homocysteine metabolism | Not graded yet | |
| Phosphatidylserine | Amount listed: 100–300 mg daily | Key component of brain cell membranes; may support memory and cognitive function | Not graded yet | |
| Acetyl-L-Carnitine | Amount listed: 1,000–2,000 mg daily in divided doses | Crosses blood-brain barrier; supports mitochondrial function; studied for cognitive disorders | Not graded yet | |
| Magnesium | Amount listed: 300–400 mg daily (consider L-threonate form) | Supports brain function; magnesium L-threonate may cross blood-brain barrier | Not graded yet | |
| Coenzyme Q10 | Amount listed: 100–200 mg daily | Mitochondrial support; antioxidant; may support brain energy metabolism | Not graded yet | |
How this protocol works
In plain language
Organic Brain Syndrome (OBS), also called organic mental disorder, refers to cognitive impairment caused by a physical (organic) cause affecting the brain. This is a broad term that includes many conditions where brain function is impaired due to disease, injury, or other physical factors.
CAUSES OF ORGANIC BRAIN SYNDROME:
- Degenerative: Alzheimer's disease, Parkinson's, Lewy body dementia
- Vascular: Stroke, vascular dementia, chronic hypoperfusion
- Metabolic: Liver disease (hepatic encephalopathy), kidney failure, thyroid disorders
- Nutritional: B12 deficiency, thiamine deficiency (Wernicke-Korsakoff)
- Toxic: Alcohol, drugs, heavy metals, medications
- Infectious: HIV, syphilis, Lyme disease, prion diseases
- Traumatic: Head injury, chronic traumatic encephalopathy
- Tumors: Brain tumors, metastatic cancer
- Other: Normal pressure hydrocephalus, sleep apnea
CRITICAL: Finding and treating the underlying cause is essential. Some causes are reversible.
MEDICAL EVALUATION should include:
- Complete blood count, metabolic panel
- Thyroid function tests
- Vitamin B12, folate levels
- Liver and kidney function
- Infectious disease testing if indicated
- Brain imaging (CT or MRI)
- Neurological examination
- Cognitive testing
REVERSIBLE CAUSES to rule out:
- B12 deficiency
- Thyroid disease
- Normal pressure hydrocephalus
- Medication effects
- Infections
- Depression (pseudodementia)
Vitamin B12* deficiency is a treatable cause of cognitive impairment.
Omega-3 Fatty Acids* support brain structure and function.
Ginkgo Biloba* may improve cerebral blood flow.
Citicoline* supports brain cell membrane repair.
Expected timeline: Reversible causes may improve within weeks to months of treatment. Degenerative conditions are managed long-term with goals of slowing progression and supporting function.