Protocol · Mental Health
Neurasthenia (Chronic Fatigue/Nervous Exhaustion) Support Protocol
Rhodiola Rosea and B-Complex Vitamins are the core of this stack, with 7 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Neurasthenia (Chronic Fatigue/Nervous Exhaustion) Support.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
9 supplements · none graded yet · 1 confirmed study
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Rhodiola Rosea | Amount listed: 200–400 mg standardized extract daily | Adaptogen that reduces fatigue and improves stress resilience; studied for burnout and exhaustion | Not graded yet | ||
Confirmed studies for Rhodiola Rosea (titles as PubMed lists them) | |||||
| B-Complex Vitamins | Amount listed: High-potency B-complex daily | Essential for energy metabolism and nervous system function; deficiency causes fatigue | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Ashwagandha | Amount listed: 300–600 mg standardized extract daily | Adaptogen that reduces stress and anxiety; may improve energy and vitality | Not graded yet | ||
| Magnesium | Amount listed: 300–400 mg daily | Deficiency common; supports energy production and nervous system function | Not graded yet | ||
| Coenzyme Q10 | Amount listed: 100–200 mg daily | Essential for cellular energy production; may reduce fatigue | Not graded yet | ||
| Iron | Amount listed: Only if ferritin <50; dose based on deficiency severity | Deficiency is common cause of fatigue especially in women; test before supplementing | Not graded yet | ||
| Vitamin D | Amount listed: 2,000–4,000 IU daily | Deficiency associated with fatigue and low mood; common in indoor populations | Not graded yet | ||
| L-Theanine | Amount listed: 100–200 mg daily | Promotes calm alertness; reduces anxiety without sedation; from green tea | Not graded yet | ||
| Omega-3 Fatty Acids | Amount listed: 2–3 g EPA+DHA daily | Anti-inflammatory; supports brain function and mood | Not graded yet | ||
Shop this protocol
Each opens third-party tested products, matched to the dose above where we can.
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How this protocol works
In plain language
Neurasthenia is an older term for a condition characterized by chronic fatigue, weakness, irritability, and difficulty concentrating. While the term is less commonly used in Western medicine today (often classified as chronic fatigue syndrome, burnout, or somatic symptom disorder), it remains a recognized diagnosis in some countries and in the ICD-10 classification.
SYMPTOMS of neurasthenia:
- Persistent mental and/or physical fatigue
- Difficulty concentrating
- Irritability and mood changes
- Sleep disturbances
- Headaches
- Muscle tension and aches
- Sensitivity to noise or light
- Digestive problems
COMMON CAUSES:
- Chronic stress and overwork (burnout)
- Anxiety and depression
- Sleep deprivation
- Nutritional deficiencies
- Underlying medical conditions
- Recovery from illness
MEDICAL EVALUATION should include:
- Thyroid function tests
- Complete blood count
- Iron studies (ferritin)
- Vitamin B12 and D levels
- Blood glucose
- Assessment for depression and anxiety
LIFESTYLE MODIFICATIONS:
- Stress management (critical)
- Regular moderate exercise
- Sleep hygiene
- Work-life balance
- Relaxation techniques
- Social support
Rhodiola Rosea* is an adaptogen that helps the body cope with stress and reduces fatigue.
B Vitamins* are essential for energy metabolism and nervous system function.
Ashwagandha* reduces stress and may improve energy levels.
Magnesium and Iron* deficiencies are common causes of fatigue that should be corrected.
Expected timeline: Adaptogens typically show benefit within 2-4 weeks. Correcting nutritional deficiencies may take 4-8 weeks. Full recovery from burnout often requires months of lifestyle changes.